39915

七(2,6-二-O-甲基)-β-环糊精

≥98.0% (TLC)

• 别名: 2,6-二-O-甲基-β-环糊精, 二甲基 β-环糊精
• 经验公式（希尔记法）: C₅₆H₉₈O₃₅
• CAS号: 51166-71-3
• 分子量: 1331.36
• Beilstein: 1679144
• MDL编号: MFCD00011616
• UNSPSC代码: 12352005
• PubChem化学物质编号: 57649911
• NACRES: NA.22

属性

• 质量水平: 100
• 方案: ≥98.0% (TLC)
• 旋光性: [α]20/D +158±3°, c = 10% in H₂O
• 杂质: ≤3% water
• SMILES字符串: COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](OC)[C@H](O[C@@H]3COC)O[C@H]4[C@H](O)[C@@H](OC)[C@H](O[C@@H]4COC)O[C@H]5[C@H](O)[C@@H](OC)[C@H](O[C@@H]5COC)O[C@H]6[C@H](O)[C@@H](OC)[C@H](O[C@@H]6COC)O[C@H]7[C@H](O)[C@@H](OC)[C@H](O[C@@H]7COC)O[C@H]8[C@H](O)[C@@H](OC)[C@H](O[C@@H]8COC)O[C@H]1[C@H](O)[C@H]2OC
• InChI: 1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3/t22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-/m1/s1
• InChI key: QGKBSGBYSPTPKJ-UZMKXNTCSA-N

说明

一般描述

Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a water-soluble derivative of cyclodextrin that exhibits the ability to effectively dissolve lipophilic drugs like steroid hormones, vitamins A, E, and K, etc. It can be used to improve the solubility and bioavailability of weakly hydrophilic pharmaceutical compounds.[1]

应用

涉及的反应物：

• 包合物的理化研究
• 与重组膜蛋白的探测扩散和单分子相互作用
• 与胶束的相互作用导致胶束破裂
• 研究细胞转运，用作细胞渗透促进剂
• 药物的理化和生物药剂学改进 ，特别是溶解和稳定性
• 与胆固醇的相互作用

Heptakis(2,6-di-O-methyl)-β-cyclodextrin may be used:

• To measure the equilibrium constant of its complexes with various enantiomeric pairs of chiral nitroxides by electron paramagnetic resonance (EPR) spectroscopy.[2]
• To study the crystal structure of its complex with n-butyl acrylate and isobornyl acrylate using X-ray diffraction (XRD).[3]
• As a chiral selector to resolve amphetamine related drugs[4] and reduced haloperidol[5] by capillary zone electrophoresis.
• As a component of thermosensitive polyurethane copolymers for their subsequent analysis by gel permeation chromatography (GPC).[6]

其他说明

复合物比相应的 β-环糊精复合物具有更高的水溶性[7]；刺激脂肪酸的合成[8]

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)