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5.00554

Sigma-Aldrich

MHY1485

≥97% (HPLC), solid, mTOR activator, Calbiochem®

Synonym(s):

mTOR Activator, MHY1485, 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine, Autophagy Inhibitor III

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About This Item

Empirical Formula (Hill Notation):
C17H21N7O4
CAS Number:
326914-06-1
Molecular Weight:
387.39
UNSPSC Code:
12352200
PubChem Substance ID:
2026662
NACRES:
NA.77

product name

mTOR Activator, MHY1485,

Assay

≥97% (HPLC)

Quality Level

100

form

solid

potency

~2 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 12.5 mg/mL

storage temp.

2-8°C

SMILES string

C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O

General description

MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.

Application

mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).

Biochem/physiol Actions

Cell permeable: yes
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Choi, Y. J., et al. 2012. PLoS. One.7, e43418.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tumor necrosis factor alpha-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson?s disease via the NFkappaB and mTOR pathways
Chi M, et al.
Neuroscience Letters, 805, 137223-137223 (2023)
Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
Choi YJ, et al.
Testing (2012)
Yeon Ja Choi et al.
PloS one, 7(8), e43418-e43418 (2012-08-29)
Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via the lysosomal pathway. During the autophagic process, cells form double-membraned vesicles called autophagosomes that sequester disposable materials in the cytoplasm and finally fuse
Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
Choi YJ, et al.
PLoS ONE (2012)
MHY1485 activates mTOR and protects osteoblasts from dexamethasone
Zhao S, et al.
Biochemical and biophysical research communications, 481(3-4), 212-218 (2016)

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