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Mepivacaine hydrochloride

Name: Mepivacaine hydrochloride
Brand: USP
Price: 455 USD
Availability: InStock

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1-Methyl-2′,6′-pipecoloxylidine hydrochloride, N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride

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Pack Size	SKU	Availability	Price
200 mg		Available to ship TODAYfromMILWAUKEE	$455.00

About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₂N₂O · HCl

CAS Number:

1722-62-9

Molecular Weight:

282.81

NACRES:

NA.24

PubChem Substance ID:

329750362

UNSPSC Code:

41116107

MDL number:

MFCD00144738

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Properties

grade

pharmaceutical primary standard

agency

USP

API family

mepivacaine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CN1CCCCC1C(NC2=C(C)C=CC=C2C)=O.Cl

InChI

1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H

InChI key

RETIMRUQNCDCQB-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Local anesthetic. Reversibly blocks transient Na⁺ inward current, as well as the steady-state K⁺ outward current.

Local anesthetic. Reversibly blocks transient Na⁺ inward current, as well as the steady-state K⁺ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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This Item	M0370000	BP699	PHR1955
USP 1387002 Mepivacaine hydrochloride	M0370000 Mepivacaine hydrochloride	BP699 Mepivacaine hydrochloride	Supelco PHR1955 Mepivacaine hydrochloride
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard
manufacturer/tradename USP	manufacturer/tradename EDQM	manufacturer/tradename BP	manufacturer/tradename -
format neat	format neat	format neat	format neat
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical
API family mepivacaine	API family mepivacaine	API family mepivacaine	API family mepivacaine
Gene Information human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)	Gene Information human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)	Gene Information human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)	Gene Information human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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pictograms

GHS06

signalword

Danger

hcodes

H301,H336

pcodes

P261 - P264 - P270 - P271 - P301 + P310 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model.

C Aumeier et al.

British journal of anaesthesia, 112(4), 735-741 (2013-10-31)

The use of lipid emulsions to reduce cardiac toxicity of local anaesthetics (LAs) has shown success in experimental studies and some clinical cases, and thus has been implemented in clinical practice. However, lipid treatment is usually given after the occurrence

Does circumferential spread of local anaesthetic improve the success of peripheral nerve block?

D Marhofer et al.

British journal of anaesthesia, 113(1), 177-185 (2014-02-28)

The relation between the pattern of local anaesthetic (LA) spread and the quality of peripheral nerve block is unclear. Twenty-one volunteers were randomized to receive a median nerve block with intended circumferential or intended non-circumferential spread of LA. Different predetermined

A prospective, randomized comparison between single- and multiple-injection techniques for ultrasound-guided subgluteal sciatic nerve block.

Hiroto Yamamoto et al.

Anesthesia and analgesia, 119(6), 1442-1448 (2014-10-01)

It is believed that local anesthetic injected to obtain circumferential spread around nerves produces a more rapid onset and successful blockade after some ultrasound-guided peripheral nerve blocks. However, evidence demonstrating this point is limited only to the popliteal sciatic nerve

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Global Trade Item Number

SKU	GTIN
1387002-200MG	04061833851432

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