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1019701

USP

Amiloride hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Amiloride hydrochloride dihydrate, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate

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About This Item

Empirical Formula (Hill Notation):
C6H8ClN7O · HCl · 2H2O
CAS Number:
17440-83-4
Molecular Weight:
302.12
MDL number:
MFCD11046655
UNSPSC Code:
41116107
NACRES:
NA.24

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grade

pharmaceutical primary standard

API family

amiloride

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl.O.O

InChI

1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2

InChI key

LTKVFMLMEYCWMK-UHFFFAOYSA-N

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1 of 4

This Item
A7410Y00019021019712
USP

USP

1019701

Amiloride hydrochloride

Amiloride hydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

A7410

Amiloride hydrochloride hydrate

vibrant-m

Y0001902

Amiloride for peak identification

Amiloride Related Compound A United States Pharmacopeia (USP) Reference Standard

USP

1019712

Amiloride Related Compound A

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

EDQM

manufacturer/tradename

USP

grade

pharmaceutical primary standard

grade

-

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

format

neat

format

-

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

pharmaceutical (small molecule)

API family

amiloride

API family

-

API family

amiloride

API family

amiloride

General description

Amiloride hydrochloride is a photosensitive yellow powder used as a mild diuretic drug.[1]

Application

Amiloride hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amiloride Hydrochloride and Hydrochlorothiazide Tablets
  • Amiloride Hydrochloride Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Matthias Schoenberger et al.
Expert opinion on therapeutic patents, 23(10), 1383-1389 (2013-08-21)
Novel molecular platforms for epithelial sodium channel (ENaC) modulators are claimed in the following six patents: WO2012035158(A1); WO2009074575(A2); WO2011028740(A1); WO2009150137(A2); WO2011079087(A1); WO2008135557(A1). These ENaC inhibitors may be used in blocking transepithelial sodium and consequently water absorption across airway epithelia. This
Hector Rasgado-Flores et al.
American journal of physiology. Cell physiology, 305(11), C1114-C1122 (2013-08-30)
Hypertonic saline (HS) inhalation therapy benefits cystic fibrosis (CF) patients [Donaldson SH, Bennet WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. N Engl J Med 354: 241-250, 2006; Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks
Mónica C F Ferraro et al.
Journal of pharmaceutical and biomedical analysis, 30(4), 1121-1131 (2002-11-01)
The use of multivariate spectrophotometric calibration for the simultaneous analysis of synthetic samples and commercial tablet preparations containing hydrochlorothiazide (HCT) and amiloride hydrochloride (AMH) is reported. Partial least squares (PLS-1) analysis of electronic absorption spectral data allowed the rapid and
Shujie Shi et al.
American journal of physiology. Renal physiology, 305(11), F1585-F1592 (2013-10-11)
The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (Po) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits
Anne P Sinke et al.
American journal of physiology. Renal physiology, 306(5), F525-F533 (2013-12-20)
Lithium is the most common cause of nephrogenic diabetes insipidus (Li-NDI). Hydrochlorothiazide (HCTZ) combined with amiloride is the mainstay treatment in Li-NDI. The paradoxical antidiuretic action of HCTZ in Li-NDI is generally attributed to increased sodium and water uptake in
View All Related Papers

Global Trade Item Number

SKUGTIN
1019701-500MG04061838668691

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