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U101

5-Methylurapidil

solid

Synonym(s):

5-Methyl-6[[3-[4-(2-methoxyphenyl)-1-piperazinyl]­propyl]­amino]-1,3-dimethyluracil

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Size/SKUAvailabilityPrice
10 mg

Estimated to ship onMay 26, 2026fromMILWAUKEE

$115.00

About This Item

Empirical Formula (Hill Notation):
C21H31N5O3
CAS Number:
34661-85-3
Molecular Weight:
401.50
NACRES:
NA.77
PubChem Substance ID:
24277800
UNSPSC Code:
12352200
MDL number:
MFCD00078602
Form:
solid

$115.00

Estimated to ship onMay 26, 2026Details

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form

solid

Quality Segment

100

color

white

solubility

H2O: 0.4 mg/mL, 0.1 M HCl: 3.8 mg/mL

SMILES string

Cl[H].COc1ccccc1N2CCN(CCCNC3=C(C)C(=O)N(C)C(=O)N3C)CC2

InChI

1S/C21H31N5O3.ClH/c1-16-19(23(2)21(28)24(3)20(16)27)22-10-7-11-25-12-14-26(15-13-25)17-8-5-6-9-18(17)29-4;/h5-6,8-9,22H,7,10-15H2,1-4H3;1H

InChI key

WAZDYFHTLYHMKO-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Application

5-Methylurapidil has been used for competitive binding in radioligand binding assays[1].

Biochem/physiol Actions

Selective α1A-adrenoceptor antagonist; antihypertensive.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

5-Methylurapidil is soluble in water at 0.4 mg/ml and is also soluble in 0.1 M HCl at 3.8 mg/ml.

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This Item
U3885Z101D122
5-Methylurapidil solid

Sigma-Aldrich

U101

5-Methylurapidil

UK-78282 monohydrochloride ≥98% (HPLC)

Sigma-Aldrich

U3885

UK-78282 monohydrochloride

Zimelidine dihydrochloride solid

Sigma-Aldrich

Z101

Zimelidine dihydrochloride

Domperidone powder, ≥98% (HPLC)

Sigma-Aldrich

D122

Domperidone

form

solid

form

solid

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

solubility

H2O: 0.4 mg/mL, 0.1 M HCl: 3.8 mg/mL

solubility

DMSO: >10 mg/mL

solubility

0.1 M HCl: 45 mg/mL, H2O: 66 mg/mL

solubility

DMSO: >10 mg/mL, 0.1 M HCl: soluble, 0.1 M NaOH: slightly soluble, H2O: insoluble

color

white

color

white to off-white

color

white

color

white

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Gene Information

-

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), KCNH2(3757)
rat ... Drd1a(24316), Drd2(24318), Drd3(29238), Htr3a(79246)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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