S8951

SR11237

Name: SR11237
Brand: SIGMA
Price: 147 USD

≥98% (HPLC)

Synonym(s):

4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid, BMS 188649, BMS649

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₈O₄

CAS Number:

146670-40-8

Molecular Weight:

380.48

NACRES:

NA.77

PubChem Substance ID:

329824615

UNSPSC Code:

12352200

MDL number:

MFCD00864137

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >28 mg/mL (warmed)

storage temp.

2-8°C

SMILES string

CC1(C)CCC(C)(C)c2cc(ccc12)C3(OCCO3)c4ccc(cc4)C(O)=O

InChI

1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)

InChI key

ZZUKALQMHNSWTK-UHFFFAOYSA-N

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This Item	SML2015	SML0397	SML0282
Sigma-Aldrich S8951 SR11237	Sigma-Aldrich SML2015 MM11253	Sigma-Aldrich SML0397 DR2313	Sigma-Aldrich SML0282 Bexarotene
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: >28 mg/mL (warmed)	solubility DMSO: 2 mg/mL, clear	solubility H₂O: >2 mg/mL (warmed)	solubility DMSO: ≥15 mg/mL (warmed)
color white to off-white	color white to beige	color white to beige	color white to beige

Application

SR11237 may be used in RXR-mediated cell signaling studies.

Biochem/physiol Actions

SR11237 and other ligands of retinoid X receptor (RXR) activate various nuclear receptors during development process. This produces malformations in Xenopus embryos, involving the anterior-posterior axis.¹

SR11237 is a pan retinoid X receptor (RXR) agonist.

SR11237 is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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[Effect of retinoid X receptor activation on oxidized low-density lipoprotein induced cell differentiation of murine macrophage cell line into dendritic like cells].

Ling-hong Shen et al.

Zhonghua xin xue guan bing za zhi, 35(9), 833-837 (2007-12-12)

To investigate the effect and related mechanism of retinoid X receptor (RXR) activation on oxidized low-density lipoprotein (ox-LDL) induced differentiation of macrophage into dendritic cell. RAW264.7 murine macrophage cell line was cultured with ox-LDL for 48 h in the absence

Retinoid X receptor-selective ligands produce malformations in Xenopus embryos.

S Minucci et al.

Proceedings of the National Academy of Sciences of the United States of America, 93(5), 1803-1807 (1996-03-05)

Retinoids exert pleiotropic effects on the development of vertebrates through the action of retinoic acid receptors (RAR) and retinoid X receptors (RXR). We have investigated the effect of synthetic retinoids selective for RXR and RAR on the development of Xenopus

Endogenous retinoid X receptors can function as hormone receptors in pituitary cells.

K D Davis et al.

Molecular and cellular biology, 14(11), 7105-7110 (1994-11-01)

Retinoids regulate gene transcription by interacting with both retinoic acid (RA) receptors (RARs) and retinoid X receptors (RXRs). Since unliganded RXRs can act as heterodimerization partners for RARs and other nuclear hormone receptors, it is unclear whether ligand binding by

The "Phantom Effect" of the Rexinoid LG100754: structural and functional insights.

Yoshiteru Sato et al.

PloS one, 5(11), e15119-e15119 (2010-12-15)

Retinoic acid receptors (RARs) and Retinoid X nuclear receptors (RXRs) are ligand-dependent transcriptional modulators that execute their biological action through the generation of functional heterodimers. RXR acts as an obligate dimer partner in many signalling pathways, gene regulation by rexinoids

Differentiation of myeloid cell lines correlates with a selective expression of RIZ protein.

P Gazzerro et al.

Molecular medicine (Cambridge, Mass.), 7(8), 552-560 (2001-10-10)

The retinoblastoma-interacting zinc-finger gene RIZ is expressed in two forms (RIZ1 and RIZ2) that differ for the presence near the N-terminus of RIZ1 of a conserved domain, defined PR (PRDI-BF1-RIZ homology), homologous to a similar domain present in other proteins

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Global Trade Item Number

SKU	GTIN
S8951-25MG	04061832954684
S8951-5MG	04061832954691

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SR11237