S8251

Succinylcholine chloride dihydrate

98.0-102.0%, Cholinergic antagonist, solid

• Synonym(s): Bis(trimethylammonioethyl) succinate chloride, Succinyldicholine dichloride
• Linear Formula: [(CH₃)₃NCH₂CH₂OCOCH₂]₂Cl₂ · 2H₂O
• CAS Number: 6101-15-1
• Molecular Weight: 397.34
• NACRES: NA.77
• PubChem Substance ID: 24277873
• UNSPSC Code: 41116107
• EC Number: 200-747-4
• MDL number: MFCD00150564
• Beilstein/REAXYS Number: 3922827
• Assay: 98.0-102.0%
• Form: solid

Properties

• Product Name: Succinylcholine chloride dihydrate, 98.0-102.0%, solid
• Quality Segment: 100
• assay: 98.0-102.0%
• form: solid
• color: white
• solubility: H₂O: complete 100 mg/ml, clear to slightly hazy, colorless, H₂O: soluble (unstable at pH > 9.)
• originator: Novartis
• SMILES string: O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
• InChI: 1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2
• InChI key: FFSBEIRFVXGRPR-UHFFFAOYSA-L

Description

Application

Succinylcholine chloride dehydrate was used to study the mechanism of gating of Cys loop receptors in Xenopus laevis.^4,5

Biochem/physiol Actions

Cholinergic antagonist which induces a long-lasting depolarization of the acetylcholine neuron membrane; neuromuscular blocking agent.

Succinylcholine is a cholinergic antagonist and a neuromuscular blocking agent. It induces depolarization of acetylcholine receptors on the muscle membrane and efflux of potassium from the muscle that leads to hypokalemia in individuals with upregulated expression of acetylcholine receptors.³

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Solutions may be stored for several days at 4 °C.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)