S5576
SKA-31
≥98% (HPLC)
Synonym(s):
Naphtho[1,2-d]thiazol-2-ylamine
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Available to ship TODAYfromMILWAUKEE | $122.00 | |
| 25 mg | Available to ship TODAYfromMILWAUKEE | $677.00 |
About This Item
Empirical Formula (Hill Notation):
C11H8N2S
CAS Number:
Molecular Weight:
200.26
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
$122.00
Available to ship TODAYDetails
Quality Segment
assay
≥98% (HPLC)
form
solid
solubility
DMSO: ≥30 mg/mL
storage temp.
−20°C
SMILES string
Nc1nc2c(ccc3ccccc23)s1
InChI
1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
InChI key
FECQXVPRUCCUIL-UHFFFAOYSA-N
Biochem/physiol Actions
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels.
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form solid | form powder | form powder | form solid |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. room temp |
| solubility DMSO: ≥30 mg/mL | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: >10 mg/mL, H2O: insoluble |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S5576-5MG | 04061833235331 |
| S5576-25MG | 04061833235324 |