Key Documents

View All Documentation

Sulindac sulfide

Name: Sulindac sulfide
Brand: SIGMA
Price: 108 USD
Availability: InStock

≥98% (HPLC), solid

Synonym(s):

(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

Select a Size

Change View

Pack Size	SKU	Availability	Price
5 mg		Available to ship TODAYfromMILWAUKEE	$108.00
25 mg		Available to ship TODAYfromMILWAUKEE	$462.00

About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₇FO₂S

CAS Number:

32004-67-4

Molecular Weight:

340.41

NACRES:

NA.77

PubChem Substance ID:

24899543

UNSPSC Code:

12352200

EC Number:

250-892-2

MDL number:

MFCD00869764

Assay:

≥98% (HPLC)

Form:

solid

$108.00

Available to ship TODAYDetails

Request a Bulk Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Segment

200

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: ≥22 mg/mL

SMILES string

[H]\C(c1ccc(SC)cc1)=C2/C(C)=C(CC(O)=O)c3cc(F)ccc23

InChI

1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChI key

LFWHFZJPXXOYNR-MFOYZWKCSA-N

Description

Application

Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.[1]

Biochem/physiol Actions

Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells[2][3] and reduces tumor burden in adenomatous polyposis patients.[4]

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	574102	G5918	I117
Sigma-Aldrich S3131 Sulindac sulfide	Sigma-Aldrich 574102 Sulindac Sulfide	Sigma-Aldrich G5918 GR 113808	Sigma-Aldrich I117 R(+)-IAA-94
form solid	form solid	form solid	form solid
assay ≥98% (HPLC)	assay ≥98% (TLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 100
solubility DMSO: ≥22 mg/mL	solubility DMSO: 25 mg/mL, ethanol: 5 mg/mL	solubility DMSO: >20 mg/mL	solubility H₂O: 0.2 mg/mL, 0.1 M NaOH: 2.8 mg/mL, DMSO: >20 mg/mL, ethanol: 20 mg/mL, dilute aqueous acid: insoluble
color yellow	color yellow-orange	color white to light pink	color white

Still not finding the right product?

Explore all of our products under Sulindac sulfide

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H317,H334,H361

pcodes

P201 - P280 - P301 + P312 + P330 - P302 + P352 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000499838

0000421266

0000300188

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKU	GTIN
S3131-5MG	04061836921538
S3131-25MG	04061832982182

Questions

Reviews

No rating value