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Phenylarsine oxide

Name: Phenylarsine oxide
Brand: SIGMA
Price: 76.8 USD
Availability: InStock

synthetic (organic), ≥97%, tyrosine phosphatase inhibitor, powder

Synonym(s):

Arzene, Oxophenylarsine, PAO

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Pack Size	SKU	Availability	Price
1 g		Available to ship TODAYfromMILWAUKEE	$76.80
5 g		Available to ship TODAYfromMILWAUKEE	$263.00

About This Item

Empirical Formula (Hill Notation):

C₆H₅AsO

CAS Number:

637-03-6

Molecular Weight:

168.02

NACRES:

NA.77

PubChem Substance ID:

24898387

UNSPSC Code:

12352119

EC Number:

211-275-3

MDL number:

MFCD00001990

Beilstein/REAXYS Number:

2935227

Assay:

≥97%

Form:

powder

$76.80

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Properties

Product Name

Phenylarsine oxide, ≥97%, powder

biological source

synthetic (organic)

Quality Segment

100

assay

≥97%

form

powder

color

white to off-white

mp

145-148 °C

solubility

DMSO: 50 mg/mL

SMILES string

O=[As]c1ccccc1

InChI

1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H

InChI key

BQVCCPGCDUSGOE-UHFFFAOYSA-N

Description

General description

Phenylarsine oxide (PhAsO⁴) is a bifunctional SH group chemical. It is hydrophobic in nature.

Application

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Biochem/physiol Actions

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	521000-M	182028	82320
Sigma-Aldrich P3075 Phenylarsine oxide	Millipore 521000-M Phenylarsine Oxide	Sigma-Aldrich 182028 Poly(ethylene oxide)	Sigma-Aldrich 82320 (±)-Propylene oxide
assay ≥97%	assay ≥96% (titration)	assay -	assay ≥99.5% (GC)
form powder	form solid	form powder	form liquid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
solubility DMSO: 50 mg/mL	solubility chloroform: 100 mg/mL, DMSO: 50 mg/mL	solubility -	solubility -
color white to off-white	color white	color -	color -
mp 145-148 °C	mp -	mp -	mp −112 °C (lit.)