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Pindolol

Name: Pindolol
Brand: SIGMA
Price: 107 USD
Availability: InStock

≥98% (TLC), β1-adrenoceptor antagonist, powder

Synonym(s):

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

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Pack Size	SKU	Availability	Price
250 mg		Available to ship TODAYfromMILWAUKEE	$107.00
1 g		Check Cart for Availability	$146.00

About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₀N₂O₂

CAS Number:

13523-86-9

Molecular Weight:

248.32

NACRES:

NA.77

PubChem Substance ID:

24277795

UNSPSC Code:

12352200

EC Number:

236-867-9

MDL number:

MFCD00010530

Assay:

≥98% (TLC)

Form:

powder

$107.00

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Properties

Product Name

Pindolol, ≥98% (TLC), powder

Quality Segment

200

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

167-171 °C (lit.)

solubility

0.1 M NaOH: 0.2 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, acetic acid: 50 mg/mL, H₂O: insoluble

originator

Novartis

storage temp.

2-8°C

SMILES string

CC(C)NCC(O)COc1cccc2[nH]ccc12

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

InChI key

JZQKKSLKJUAGIC-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), HTR1A(3350)

Description

Application

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Biochem/physiol Actions

β₁-adrenoceptor antagonist; putative 5-HT_1A serotonin receptor agonist; vasodilator.

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.

Features and Benefits

Shelf-life of the powder is at least five years.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	P8688	SML1913	P0884
Sigma-Aldrich P0778 Pindolol	Sigma-Aldrich P8688 (S)-(−)-Propranolol hydrochloride	Sigma-Aldrich SML1913 ASB14780	Sigma-Aldrich P0884 (±)-Propranolol hydrochloride
assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥98% (HPLC)	assay ≥99% (TLC)
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility 0.1 M NaOH: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, H₂O: insoluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, acetic acid: 50 mg/mL	solubility ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL	solubility DMSO: 10 mg/mL, clear	solubility ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
color white to off-white	color -	color white to beige	color white