P0643

5-Propyl-2-thiouracil

Name: 5-Propyl-2-thiouracil
Brand: SIGMA
Price: 325 USD
Availability: InStock

≥98%

Synonym(s):

PTU

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100 MG

$325.00

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About This Item

Empirical Formula (Hill Notation):

C₇H₁₀N₂OS

CAS Number:

2954-52-1

Molecular Weight:

170.23

NACRES:

NA.51

PubChem Substance ID:

24898118

UNSPSC Code:

41106305

MDL number:

MFCD00057340

Assay:

≥98%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow

Key Documents

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biological source

synthetic (organic)

Quality Level

100

assay

≥98%

form

powder

solubility

1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow

SMILES string

CCCC1=CNC(=S)NC1=O

InChI

1S/C7H10N2OS/c1-2-3-5-4-8-7(11)9-6(5)10/h4H,2-3H2,1H3,(H2,8,9,10,11)

InChI key

RWJRFPUNLXBCML-UHFFFAOYSA-N

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This Item	C9375	T7750	P3252
Sigma-Aldrich P0643 5-Propyl-2-thiouracil	Sigma-Aldrich C9375 5-Carboxy-2-thiouracil	T7750 2-Thiouracil	Sigma-Aldrich P3252 6-Phenyl-2-thiouracil
biological source synthetic (organic)	biological source synthetic (organic)	biological source synthetic	biological source synthetic (organic)
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
form powder	form powder	form powder	form powder
assay ≥98%	assay ≥98% (TLC)	assay ≥99%	assay ≥95%
solubility 1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow	solubility 1 M NaOH: 50 mg/mL, clear, colorless to faintly yellow	solubility 1 M NaOH: 5 mg/mL, clear to very slightly hazy, 1 M NaOH: 50 mg/mL, colorless to faintly yellow	solubility DMF: 20 mg/mL, clear to slightly hazy, colorless to light yellow

Application

5-Propyl-2-thiouracil (PTU) is used to induce and study mechanisms of hypothyroidism at the levels of thyroid hormone biosynthesis and gene regulation.

pictograms

GHS08

signalword

Warning

hcodes

H351

pcodes

P281

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization.

Ayumi Nagasawa-Masuda et al.

PloS one, 12(4), e0174633-e0174633 (2017-04-04)

Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress

Integration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products.

Nadine Bohni et al.

PloS one, 8(5), e64006-e64006 (2013-05-24)

Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect to NP discovery, including the time and effort required for bioassay-guided isolation of bioactive NPs, and the limited biomedical relevance

Orthotopic transplantation of retinoblastoma cells into vitreous cavity of zebrafish for screening of anticancer drugs.

Dong Hyun Jo et al.

Molecular cancer, 12, 71-71 (2013-07-10)

With high throughput screening, novel therapeutic agents can be efficiently identified. Unfortunately, researchers only resort to in vitro cell viability assays for screening of anticancer drugs for retinoblastoma, the most common intraocular cancer in the childhood. Current available animal models

Visual acuity in larval zebrafish: behavior and histology.

Marion F Haug et al.

Frontiers in zoology, 7, 8-8 (2010-03-03)

Visual acuity, the ability of the visual system to distinguish two separate objects at a given angular distance, is influenced by the optical and neuronal properties of the visual system. Although many factors may contribute, the ultimate limit is photoreceptor

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo.

Nynke Oosterhof et al.

Cell reports, 24(5), 1203-1217 (2018-08-02)

Microglia are brain-resident macrophages with trophic and phagocytic functions. Dominant loss-of-function mutations in a key microglia regulator, colony-stimulating factor 1 receptor (CSF1R), cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a progressive white matter disorder. Because it remains

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Global Trade Item Number

SKU	GTIN
P0643-1G	04061834332091
P0643-100MG	04061833049792

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5-Propyl-2-thiouracil