M5793

3-Morpholinosydnonimine hydrochloride

guanylyl cyclase activator

• Synonym(s): 3-(4-Morpholinyl)sydnone imine hydrochloride, Linsidomine hydrochloride, SIN-1 hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₀N₄O₂ · HCl
• CAS Number: 16142-27-1
• Molecular Weight: 206.63
• UNSPSC Code: 12352200
• PubChem Substance ID: 24897048
• NACRES: NA.77
• MDL number: MFCD00214332

Properties

• Product Name: 3-Morpholinosydnonimine hydrochloride, (consistent with structure, NMR)
• Quality Segment: 200
• storage temp.: −20°C
• SMILES string: Cl[H].[NH-]c1c[n+](no1)N2CCOCC2
• InChI: 1S/C6H10N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5,7H,1-4H2;1H
• InChI key: NCGICGYLBXGBGN-UHFFFAOYSA-N

Description

Application

3-Morpholinosydnonimine hydrochloride has been used:

• as a peroxynitrite donor standard to study the accumulation of peroxynitrite in Arabidopsis thaliana[1]
• to study its effects on nitrosative stress in human brain vascular pericytes and human embryonic kidney cells[2]
• as a ROS to study its effects on mouse embryonic fibroblasts[3]

Biochem/physiol Actions

3-Morpholinosydnonimine participates in the inhibition of cysteine proteases.[4]

Liberates nitric oxide (NO) spontaneously when in solution, activating guanylyl cyclase and causing an increase in cyclic-GMP. This product is a vasodilator and inhibits platelet aggregation. Using molecular oxygen, it generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite.

Liberates nitric oxide (NO) spontaneously when in solution, activating guanylyl cyclase and causing an increase in cyclic-GMP; vasodilator.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)