This product is not assigned an expiration date or product retest date. Products that are robust in nature and extremely stable, in the original unopened container, are not assigned an expiration date or retest schedule. Products that are not assigned an expiration or retest date are covered by a warranty period of 1 year from the date of product shipment.
M5525
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester
≥98%, powder
Synonym(s):
N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCC
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Check Cart for Availability | $41.50 | |
| 25 mg | Check Cart for Availability | $124.00 | |
| 100 mg | Check Cart for Availability | $385.00 |
About This Item
Empirical Formula (Hill Notation):
C16H18N2O6
CAS Number:
Molecular Weight:
334.32
UNSPSC Code:
12352103
NACRES:
NC.07
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1555271
Assay:
≥98%
Form:
powder
Quality Segment
assay
≥98%
form
powder
reaction suitability
reagent type: linker
mp
180-182 °C (lit.)
solubility
chloroform: 50 mg/mL, DMF: soluble
functional group
NHS ester
shipped in
wet ice
storage temp.
−20°C
SMILES string
O=C(ON1C(CCC1=O)=O)C2CCC(CN3C(C=CC3=O)=O)CC2
InChI
1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2
InChI key
JJAHTWIKCUJRDK-UHFFFAOYSA-N
General description
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
Application
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for the coupling of a peptide sequence to an amino group.
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This Item | |||
|---|---|---|---|
| assay ≥98% | assay ≥98% | assay ≥98.0% (HPLC) | assay ≥95% |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| reaction suitability reagent type: linker | reaction suitability reagent type: linker | reaction suitability reagent type: linker | reaction suitability reagent type: cross-linking reagent |
| solubility chloroform: 50 mg/mL, DMF: soluble | solubility chloroform: 100 mg/mL, DMF: soluble (lit.)(lit.) | solubility - | solubility acetone: 50 mg/mL, DMF: soluble |
| mp 180-182 °C (lit.) | mp 70-73 °C (lit.) | mp 70-73 °C (lit.) | mp 84-86 °C (lit.) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| M5525-100MG | 04061834060062 |
| M5525-5MG | 04061832863047 |
| M5525-25MG | 04061832863030 |
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¿Qué caducidad se puede dar al producto M5525 almacenado a -20ºC?
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