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4-Methylpyrazole hydrochloride

Name: 4-Methylpyrazole hydrochloride
Brand: SIGMA
Price: 161 USD
Availability: InStock

alcohol dehydrogenase inhibitor

Synonym(s):

Fomepizole

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Pack Size	Availability	Price
100 mg	Available to ship TODAYfromMILWAUKEE	$161.00
500 mg	Available to ship TODAYfromMILWAUKEE	$556.00
1 g	Check Cart for Availability	$948.00

About This Item

Empirical Formula (Hill Notation):

C₄H₆N₂ · HCl

CAS Number:

56010-88-9

Molecular Weight:

118.56

NACRES:

NA.77

PubChem Substance ID:

24278534

MDL number:

MFCD00012707

UNSPSC Code:

12352100

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Properties

biological source

synthetic (organic)

Quality Segment

200

assay

≥95%

form

powder

mp

157-159 °C

solubility

methanol: 100 mg/mL, clear, colorless to yellow

storage temp.

2-8°C

SMILES string

Cl.Cc1cn[nH]c1

InChI

1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H

InChI key

PUCXJHNDMYZOHG-UHFFFAOYSA-N

Gene Information

human ... ADH1A(124), ADH1B(125), ADH1C(126)

Description

Application

4-Methylpyrazole hydrochloride has been used:

as a cytochrome P450 2E1 inhibitor[1]
as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells[2]
to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells[3]

Useful as an antidote in methanol and ethylene glycol poisoning.

Biochem/physiol Actions

4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes.[4] It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.[5]

Alcohol dehydrogenase inhibitor

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Show Differences

1 of 1

This Item	C13408	B6506	M6500
Sigma-Aldrich M1387 4-Methylpyrazole hydrochloride	Sigma-Aldrich C13408 O-(Carboxymethyl)hydroxylamine hemihydrochloride	Sigma-Aldrich B6506 Benzamidine hydrochloride hydrate	Sigma-Aldrich M6500 Cysteamine hydrochloride
assay ≥95%	assay 98%	assay ≥99%	assay ≥98% (titration)
biological source synthetic (organic)	biological source synthetic (organic)	biological source synthetic (organic)	biological source synthetic (organic)
Gene Information human ... ADH1A(124), ADH1B(125), ADH1C(126)	Gene Information -	Gene Information -	Gene Information -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 300
form powder	form crystalline powder, powder or crystals	form powder	form powder or crystals
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Global Trade Item Number

SKU	GTIN
M1387-100MG	04061834038214
M1387-1G	04061826691663
M1387-500MG	04061832948157

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