M0199

Mdivi-1

≥98% (HPLC), powder, mitochondrial division DRP inhibitor

• Synonym(s): 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone
• Empirical Formula (Hill Notation): C₁₅H₁₀Cl₂N₂O₂S
• CAS Number: 338967-87-6
• Molecular Weight: 353.22
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817738
• NACRES: NA.77
• MDL number: MFCD00974506
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Mdivi-1, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >20 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
• InChI: 1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
• InChI key: NZJKEVWTYMOYOR-UHFFFAOYSA-N

Description

General description

Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.

Application

Mdivi-1 has been used:

• in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferation[1]
• in mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)[2]
• to induce mitochondrial damage in lung fibroblasts

Biochem/physiol Actions

Mdivi-1 is a cell-permeable selective inhibitor of mitochondrial division DRP (dynamin-related GTPase) and inhibitor of the mitochondrial division dynamin (Dnm1). Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.

Mdivi-1 is a selective inhibitor of mitochondrial division DRP (dynamin-related GTPase); inhibitor of the mitochondrial division dynamin (Dnm1).

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable