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M006

Proglumide sodium salt

solid

Synonym(s):

4-Benzoylamino-5-dipropylamino-5-oxopentanoic acid sodium-potassium salt, N-Benzoyl-N′,N′-dipropyl-DL-isoglutamine sodium-potassium salt

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Pack SizeSKUAvailabilityPrice
100 mg

Estimated to ship onMarch 23, 2026fromMILWAUKEE

$197.00
500 mg

Estimated to ship onMarch 23, 2026fromMILWAUKEE

$1,240.00

About This Item

Empirical Formula (Hill Notation):
C18H25N2NaO4
CAS Number:
99247-33-3
Molecular Weight:
356.39
NACRES:
NA.77
PubChem Substance ID:
24896533
UNSPSC Code:
12352200
MDL number:
MFCD00069301
Form:
solid
Quality level:
100

$197.00

Estimated to ship onMarch 23, 2026Details

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form

solid

Quality Level

100

color

white

solubility

H2O: soluble

SMILES string

[Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)c1ccccc1

InChI

1S/C18H26N2O4.Na/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14;/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22);/q;+1/p-1

InChI key

UFMWGCINVOIJSO-UHFFFAOYSA-M

Gene Information

human ... CCK(885), CCKAR(886), CCKBR(887)
mouse ... CCK(12424)
rat ... CCK(25298)

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This Item
Z2001SML1228SML1229
Proglumide sodium salt solid

Sigma-Aldrich

M006

Proglumide sodium salt

Zonisamide sodium salt ≥98% (HPLC), powder

Sigma-Aldrich

Z2001

Zonisamide sodium salt

Cyclic-di-GMP sodium salt ≥98% (HPLC)

Sigma-Aldrich

SML1228

Cyclic-di-GMP sodium salt

2′,3′-cGAMP sodium salt ≥98% (HPLC)

Sigma-Aldrich

SML1229

2′,3′-cGAMP sodium salt

form

solid

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: soluble

solubility

H2O: >5 mg/mL

solubility

-

solubility

-

color

white

color

white to beige

color

white to beige

color

white to beige

Gene Information

human ... CCK(885), CCKAR(886), CCKBR(887)
mouse ... CCK(12424)
rat ... CCK(25298)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Gene Information

-

Gene Information

-

Application

Proglumide sodium salt has been used to study the effects of proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.

Biochem/physiol Actions

Proglumide sodium salt is a non-peptide cholecystokinin receptor antagonist that has greater selectivity for the CCKA subtype. It selectively blocks central nervous system effects. Proglumide sodium salt is orally active.
CCK antagonist; selectively blocks CNS effects.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000027600
0000022775
066M4611V
115M4609V
095M4609V

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The cholecystokinin antagonist, proglumide, increases food intake in the rat
G.Shillabeer and J. Davidson
Regulatory Peptides (1984)
E S Corp et al.
Physiology & behavior, 61(6), 823-827 (1997-06-01)
Cholecystokinin (CCK) receptors are classified as two subtypes, designated CCK(A) and CCK(B), and both subtypes are found in brain and peripheral tissues of rats. CCK-8 has been shown to act peripherally to reduce meal size, and this satiating action can
Role of cholecystokinin and its antagonist proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.
V. C. Rubio
Physiology & Behavior (2008)
J V Menani et al.
The American journal of physiology, 275(5 Pt 2), R1431-R1437 (1998-10-29)
The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II
James M Hill et al.
Science translational medicine, 6(265), 265ra169-265ra169 (2014-12-05)
Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals that target viral DNA replication. The initiation of herpes simplex virus infection and reactivation from latency
View All Related Papers

Global Trade Item Number

SKUGTIN
M006-500MG04061832677194
M006-100MG04061833992500

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