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L5793

Leupeptin

powder, ≥95% (HPLC)

Synonym(s):

Leupeptin hemisulfate salt, Acetyl-Leu-Leu-Arg-al, N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt

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Size/SKUAvailabilityPrice
5 mg
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$301.00
25 mg
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$1,020.00
100 mg
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$2,520.00

About This Item

Linear Formula:
C20H38N6O4 · 1/2H2SO4
CAS Number:
103476-89-7
Molecular Weight:
475.59
UNSPSC Code:
12352202
PubChem Substance ID:
24896420
NACRES:
NA.77
MDL number:
MFCD00037012

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Product Name

Leupeptin, BioUltra, microbial, ≥95% (HPLC)

biological source

microbial

Quality Segment

200

product line

BioUltra

assay

≥95% (HPLC)

form

powder

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

OS(O)(=O)=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O

InChI

1S/2C20H38N6O4.H2O4S/c2*1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;1-5(2,3)4/h2*11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H2,1,2,3,4)/t2*15-,16-,17-;/m00./s1

InChI key

CIPMKIHUGVGQTG-VFFZMTJFSA-N

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Analysis Note

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

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This Item
L8511LEU-RO108976
Leupeptin BioUltra, microbial, ≥95% (HPLC)

Sigma-Aldrich

L5793

Leupeptin

Leupeptin synthetic, ≥85% (HPLC)

Sigma-Aldrich

L8511

Leupeptin

Leupeptin powder, from synthetic, =96.5%

Roche

LEU-RO

Leupeptin

Leupeptin, Hemisulfate, Synthetic Synthetic version of the microbial-derived inhibitor Leupeptin against trypsin-like and cysteine protease activities.

Sigma-Aldrich

108976

Leupeptin, Hemisulfate, Synthetic

assay

≥95% (HPLC)

assay

≥85% (HPLC)

assay

96.5%

assay

≥95% (sum of isomers, HPLC)

biological source

microbial

biological source

synthetic

biological source

synthetic

biological source

-

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

300

form

powder

form

powder

form

powder

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

water: 50 mg/mL

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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