The solubility of this item is 1mg/ml as mentioned on the COA.
Link to sample COA: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/H7640-5MG0000336127.pdf
H7640
Heparan sulfate sodium salt from bovine kidney
powder, extracellular matrix component
Heparan sulfate sodium salt from bovine kidney
Synonym(s):
Heparitin sulfate sodium salt
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 mg | Available to ship TODAYfromMILWAUKEE | $221.00 | |
| 5 mg | Available to ship TODAYfromMILWAUKEE | $773.00 | |
| 10 mg | Available to ship TODAYfromMILWAUKEE | $1,360.00 |
About This Item
Application
Heparan sulfate sodium salt from bovine kidney has been used:
- to investigate its effect on proliferation of B cells[1]
- to monitor its role on eye development in E5 embryonic cells
- to study its binding with exosome fibronectin in human trabecular meshwork cells using dot blot
Biochem/physiol Actions
Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion
Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars. It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units. It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression. HS is associated with the onset of infectious diseases and inflammatory conditions. HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.Heparan sulphate is a constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion.
1 of 1
This Item | |||
|---|---|---|---|
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Articles
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
SeQuant® ZIC®-HILIC column enables efficient separation of 2-aminobenzamide-labeled GAG disaccharides for reliable proteoglycan profiling in a single run.
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H7640-5MG | 04061833804186 |
| H7640-1MG | 04061833804100 |
| H7640-10MG | 04061835557165 |
-
What solvent should i use to dissolve this?
1 answer-
Helpful?
-
-
Wo finde ich eine Angabe zum Molekulargewicht?
1 answer-
The molecular weight of this product is not determined. However, data from collective articles suggests the molecular weight could be around 14000 Da.
Helpful?
-