There's only the CoA for F8257. It's soluble at 50 mg/mL in CHCl3:MeOH (1:1) according to the CoA. Please consult the available literature for the use of solvents in in vitro testing.
F8257
Flunarizine dihydrochloride
≥98% (TLC), T-type Ca2+/Na+ channel blocker
Synonym(s):
1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 g | Available to ship TODAYfromMILWAUKEE | $92.00 | |
| 10 g | Available to ship TODAYfromMILWAUKEE | $516.00 |
About This Item
Empirical Formula (Hill Notation):
C26H26F2N2 · 2HCl
CAS Number:
Molecular Weight:
477.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
250-216-6
MDL number:
Beilstein/REAXYS Number:
4284243
Assay:
≥98% (TLC)
Product Name
Flunarizine dihydrochloride, ≥98% (TLC)
Quality Segment
assay
≥98% (TLC)
originator
Johnson & Johnson
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
InChI
1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChI key
RXKMOPXNWTYEHI-RDRKJGRWSA-N
General description
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
Application
Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
Biochem/physiol Actions
Blocks T-type Ca2+/Na+ channels.
Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay - | assay - | assay ≥98% (TLC) |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
| originator Johnson & Johnson | originator - | originator - | originator - |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| F8257-10G | 04061832961637 |
| F8257-1G | 04061833620410 |
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For in vitro testing, in what solvent can it be dissolved? DMSO or other. Also, we require product datasheet which is not available on the website
1 answer-
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