For an inhibitor for beta oxidation, the following products may be of interest:
•E1905 (+)-Etomoxir sodium salt hydrate
•5.09455 InSolution Etomoxir
•M5199 Meldonium dihydrate
E1905
(+)-Etomoxir sodium salt hydrate
≥98% (HPLC), powder, CPT-1 inhibitor
Synonym(s):
R(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt hydrate
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5 MG
$217.00
25 MG
$746.00
About This Item
Empirical Formula (Hill Notation):
C15H18ClO4 · Na · H2O
CAS Number:
Molecular Weight:
338.76
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Product Name
(+)-Etomoxir sodium salt hydrate, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: freely soluble
storage temp.
2-8°C
SMILES string
O.[Na+].[O-]C(=O)[C@@]2(CCCCCCOc1ccc(Cl)cc1)CO2
InChI
1S/C15H19ClO4.Na.H2O/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;1H2/q;+1;/p-1/t15-;;/m1../s1
InChI key
WENJLJJSJDAJDN-QCUBGVIVSA-M
General description
(+)-Etomoxir sodium salt hydrate belongs to oxirane carboxylic acid group of compounds and mediates metabolic channeling of fatty acid precursors.[1] It favors oxidative stress in T cells[2] and prevents T cell differentiation.[3] It inhibits fatty acid oxidation and promotes hunger and food intake.[4] Etomoxir impairs myeloid-derived suppressor cells mediated tumor and could have potential therapeutic potential.[5]
Application
Biochem/physiol Actions
Irreversible O-carnitine palmitoyltransferase-1 (CPT-1) inhibitor; PPARα activator
Packaging
Store tightly sealed, protected from exposure to light
also commonly purchased with this product
Product No.
Description
Pricing
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells
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Journal of Lipid Research, 44(2), 415-423 (2003)
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
OConnor RS, et al.
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Journal of lipid research, 59(7), 1276-1282 (2018-05-10)
Metabolic flexibility, the capacity to adapt to fuel availability for energy production, is crucial for maintaining whole-body energy homeostasis. An inability to adequately promote FA utilization is associated with lipid accumulation in peripheral tissues and contributes to the development of
L-carnitine ameliorates the liver inflammatory response by regulating carnitine palmitoyltransferase I-dependent PPAR gamma signaling
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