O4876

Oligomycin

from Streptomyces diastatochromogenes, ≥90% total oligomycins basis (HPLC), powder, antibiotic

• CAS Number: 1404-19-9
• Beilstein/REAXYS Number: 7615308
• MDL number: MFCD01779388
• UNSPSC Code: 12352200
• PubChem Substance ID: 24898006
• NACRES: NA.77

Properties

• product name: Oligomycin from Streptomyces diastatochromogenes, ≥90% total oligomycins basis (HPLC)
• assay: ≥90% total oligomycins basis (HPLC)
• form: powder
• antibiotic activity spectrum: fungi
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• InChI: 1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+
• InChI key: MNULEGDCPYONBU-ZUSSGZTJSA-N

Description

General description

Chemical structure: macrolide

Application

Oligomycin from Streptomyces diastatochromogenes is used:

• in the inhibition of mitochondrial ATP production Leigh syndrome (LS) cells.
• in ATP-linked respiration and maximal capacity respiration assay in astrocytes.
• in measurement of oxygen consumption rate (OCR) and extracellular acidification rates in breast cancer cell lines.

Biochem/physiol Actions

Oligomycin belongs to the macrolide group of antibiotics. It inhibits mitochondrial ATP-synthase enzyme and phosphoryl group transfer. Oligomycin interacts with ATP synthase subunit-c in the Fo portion and impairs proton transport.

Other Notes

A mixture of oligomycins A, B, and C.

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Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves