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E0159

Efonidipine hydrochloride monoethanolate

≥98% (HPLC)

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5 MG

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About This Item

Empirical Formula (Hill Notation):
C34H38N3O7P · HCl · C2H5OH
CAS Number:
111011-76-8
Molecular Weight:
714.18
NACRES:
NA.25
PubChem Substance ID:
329798945
UNSPSC Code:
12352200
MDL number:
MFCD00875717
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

pale yellow

solubility

DMSO: >5 mg/mL, H2O: insoluble

originator

Shionogi

storage temp.

2-8°C

SMILES string

Cl.CCO.CC1=C(C(c2cccc(c2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(Cc4ccccc4)c5ccccc5

InChI

1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H

InChI key

IKBJGZQVVVXCEQ-UHFFFAOYSA-N

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1 of 4

This Item
SML0346SML0807SML1261
Efonidipine hydrochloride monoethanolate ≥98% (HPLC)

Sigma-Aldrich

E0159

Efonidipine hydrochloride monoethanolate

Alosetron hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0346

Alosetron hydrochloride

PreQ1 dihydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0807

PreQ1 dihydrochloride

Asimadoline hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1261

Asimadoline hydrochloride

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >5 mg/mL, H2O: insoluble

solubility

H2O: ≥5 mg/mL at warmed

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

Biochem/physiol Actions

Efonidipine hydrochloride is a racemic compound that has some L-type as well as T-type calcium channel blocking activity.
Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(−)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.

Features and Benefits

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000520197
0000520195
0000520195
0000520197
0000512167

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Hiroki Shimada et al.
FEBS open bio, 7(9), 1410-1421 (2017-09-15)
Aldosterone synthase is the key rate-limiting enzyme in adrenal aldosterone production, and induction of its gene (
Noriaki Ikemura et al.
Chemico-biological interactions, 306, 1-9 (2019-04-10)
The inhibitory effects of antihypertensive drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors) on cytochrome P450 2J2 (CYP2J2) activity were examined. Amlodipine, azelnidipine, barnidipine, benidipine, cilnidipine, efonidipine, felodipine, manidipine, nicardipine, nifedipine, nilvadipine, nisoldipine, nitrendipine, telmisartan

Global Trade Item Number

SKUGTIN
E0159-25MG04061833600948
E0159-5MG04061833600955

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