E0156

Anti-Estrogen-Related Receptor β antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-ERRβ, Anti-NR3B2
• UNSPSC Code: 12352203
• MDL number: MFCD06798439
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC (p)
• Citations: 7

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1 μg/mL using human liver, hepatocytes
• UniProt accession no.: O95718
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ESRRB(2103) ; mouse ... Esrrb(26380) ; rat ... Esrrb(299210)

Description

Immunogen

synthetic peptide corresponding to the internal domain of human estrogen-related receptor β, conjugated to KLH. The immunizing peptide has 93% homology with the rat and mouse gene.

Application

Anti-Estrogen-Related Receptor β antibody produced in rabbit was used for immunocytochemistry of neurons from mouse model of glaucoma at a working dilution of 1:500. It was also used for immunohistochemistry of mouse brain sections.

Biochem/physiol Actions

Estrogen-Related Receptors (ERR) are hormone receptors that bind estrogen response elements that in turn bind specific DNA sequences and regulate transcription. Three ERRs are known, alpha, beta and gamma, with highly conserved ligand and DNA binding sequences. ERRβ is selectively expressed in brain and is an important modulator of energy balance, food intake, neuropeptide levels and response to stress.

Physical form

Solution in phosphate buffered saline, containing 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable