D1064

Dihydrokainic acid

≥98% (HPLC), GLT-1 glutamate transporter inhibitor, powder

• Synonym(s): 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid
• Empirical Formula (Hill Notation): C₁₀H₁₇NO₄
• CAS Number: 52497-36-6
• Molecular Weight: 215.25
• UNSPSC Code: 12352106
• PubChem Substance ID: 24277981
• NACRES: NA.77
• MDL number: MFCD03412037
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Dihydrokainic acid, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: H₂O: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
• InChI: 1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
• InChI key: JQPDCKOQOOQUSC-OOZYFLPDSA-N
• Gene Information: human ... SLC1A1(6505), SLC1A2(6506), SLC1A3(6507) ; rat ... Slc1a2(29482), Slc1a3(29483)

Description

Application

Dihydrokainic acid has been used as a glutamate transporter (GLT-1) inhibitor in the glutamate uptake assay of astrocytes[1] and glial cells.[2] It may be used as a GLT-1 inhibitor in Lateral habenula (LHb).

Biochem/physiol Actions

Dihydrokainic acid is a selective GLT-1 glutamate transporter inhibitor; weak inhibitor of AMPA/kainate glutamic acid receptors at high concentrations.

Dihydrokainic acid is a selective inhibitor of the GLT-1 glutamate transporter. At higher concentrations, dihydrokainate is a weak inhibitor of AMPA/kainate glutamic acid receptors.

Dihydrokainic favors neuronal cell death.[3] It modulates anxiety and depression behaviors.

Features and Benefits

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves