The solution stability of this product has not been determined. As indicated in the 'DESCRIPTION' section under 'Preparation Note', solutions should be freshly prepared. However, one publication tested the stability of 4.2 mM solutions of MPP+ over 28 days in the dark at 37 °C. Aliquots of the solution were taken and then stored at -80 °C for analysis by HPLC. During this period, no degradation of MPP+ was observed (Yazdani, U., et al., Rat model of Parkinson's disease: Chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+). Exp. Neurol., 200, 172-183 (2006)).
D048
MPP+ iodide
≥98% (HPLC), ERα antagonist, powder
Synonym(s):
1-Methyl-4-phenylpyridinium iodide
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 mg | Available to ship onMay 19, 2026fromMILWAUKEE | $215.00 | |
| 1 g | Available to ship onMay 19, 2026fromMILWAUKEE | $1,270.00 |
About This Item
Empirical Formula (Hill Notation):
C12H12IN
CAS Number:
Molecular Weight:
297.13
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
$215.00
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Product Name
MPP+ iodide, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
SMILES string
[I-].C[n+]1ccc(cc1)-c2ccccc2
InChI
1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChI key
RFDFRDXIIKROAI-UHFFFAOYSA-M
General description
1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.[1]induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.[2]
Application
MPP+ iodide has been used:
- to induce oxidative stress in zebrafish embryos[3]
- for the inhibition of glutamate uptake in mitochondria of astrocytes
- in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells
Biochem/physiol Actions
Active metabolite of dopaminergic neurotoxin MPTP
MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.
Preparation Note
Solutions should be freshly prepared.
Disclaimer
Photosensitive.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| D048-100MG | 04061833557709 |
| D048-1G | 04061833557716 |
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