C9847

Cyclothiazide

AMPA glutamate receptor blocker, powder

• Synonym(s): 6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Empirical Formula (Hill Notation): C₁₄H₁₆ClN₃O₄S₂
• CAS Number: 2259-96-3
• Molecular Weight: 389.88
• NACRES: NA.77
• PubChem Substance ID: 24278350
• UNSPSC Code: 12352125
• EC Number: 218-859-7
• MDL number: MFCD00210192
• Form: powder

Properties

• Product Name: Cyclothiazide,
• form: powder
• Quality Segment: 200
• originator: Eli Lilly
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12CC(C3Nc4cc(Cl)c(cc4S(=O)(=O)N3)S(N)(=O)=O)[C@@]([H])(C1)C=C2
• InChI: 1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)/t7-,8+,9?,14?/m0/s1
• InChI key: BOCUKUHCLICSIY-QJWLJZLASA-N
• Gene Information: human ... CA1(759), CA4(762), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893) ; rat ... Gria1(50592)

Description

General description

Cyclothiazide is a benzothiadiazine, which has a similar structure to diazoxide.[1]

Application

Cyclothiazide has been used as a α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) desensitization blocker to study the effects of γ2 on receptor desensitization.[2]

Biochem/physiol Actions

Blocks the rapid desensitization of the AMPA glutamate receptors and markedly prolongs the decay time of the evoked excitatory post-synaptic current.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves