C9124

CK-869

≥98% (HPLC), actin assembly inhibitor, powder

• Synonym(s): 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone, CK 869, CK-0157869
• Empirical Formula (Hill Notation): C₁₇H₁₆BrNO₃S
• CAS Number: 388592-44-7
• Molecular Weight: 394.28
• MDL number: MFCD01844129
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: CK-869, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to light gray
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S1C(N(C(=O)C1)c3c(cc(cc3)OC)OC)c2cc(ccc2)Br
• InChI: 1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3
• InChI key: MVWNPZYLNLATCH-UHFFFAOYSA-N

Description

Application

CK-869 has been used as an Arp2/3 complex inhibitor:

• to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly[1]
• to induce membrane blebbing in HT1080 fibrosarcoma cells[2]
• to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis[3]

Biochem/physiol Actions

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.[1]

CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast.

CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable