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C6303

Calphostin C

From microbial (Cladosporium cladosporioides), ≥90% (HPLC), protein kinase C inhibitor, powder

Synonym(s):

UCN-1028c

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0.1 mg

Available to ship TODAYfromMILWAUKEE

$467.00
1 mg

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$2,130.00

About This Item

Empirical Formula (Hill Notation):
C44H38O14
CAS Number:
121263-19-2
Molecular Weight:
790.76
UNSPSC Code:
12352200
PubChem Substance ID:
24892857
NACRES:
NA.77
MDL number:
MFCD00133155

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Product Name

Calphostin C from Cladosporium cladosporioides, ≥90% (HPLC), powder

biological source

microbial (Cladosporium cladosporioides)

Quality Segment

200

assay

≥90% (HPLC)

form

powder

color

red to brown

solubility

DMF: 1 mg/mL, DMSO: 1 mg/mL, ethanol: 1 mg/mL

storage temp.

−20°C

SMILES string

COc1cc(O)c2C(=O)C(OC)=C(CC(C)OC(=O)Oc3ccc(O)cc3)c4c5C(CC(C)OC(=O)c6ccccc6)=C(OC)C(=O)c7c(O)cc(OC)c(c57)c1c24

InChI

1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3

InChI key

SRJYZPCBWDVSGO-UHFFFAOYSA-N

Biochem/physiol Actions

Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.

Features and Benefits

This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Calphostin C from Cladosporium cladosporioides ≥90% (HPLC), powder

Sigma-Aldrich

C6303

Calphostin C from Cladosporium cladosporioides

(S)-(+)-Camptothecin ≥90% (HPLC), powder

Sigma-Aldrich

C9911

(S)-(+)-Camptothecin

Leupeptin hydrochloride microbial, ≥90% (HPLC)

Sigma-Aldrich

L9783

Leupeptin hydrochloride

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin ≥90% (HPLC), powder

Sigma-Aldrich

A0466

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin

biological source

microbial (Cladosporium cladosporioides)

biological source

-

biological source

microbial

biological source

-

assay

≥90% (HPLC)

assay

≥90% (HPLC)

assay

≥90% (HPLC)

assay

≥90% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMF: 1 mg/mL, ethanol: 1 mg/mL, DMSO: 1 mg/mL

solubility

chloroform/methanol (4:1): 5 mg/mL

solubility

water: 50 mg/mL, clear, colorless

solubility

H2O: 1 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000491534
0000491534
0000491532
0000491532
0000469161

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Global Trade Item Number

SKUGTIN
C6303-1MG04061833511138
C6303-.1MG04061833511121

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