C4011

Cytochrome c from pigeon breast muscle

≥95% based on Mol. Wt. 12,173 basis

• CAS Number: 9007-43-6
• UNSPSC Code: 12352202
• EC Number: 232-700-9
• NACRES: NA.61
• MDL number: MFCD00130890
• Form: powder
• Assay: ≥95% based on Mol. Wt. 12,173 basis
• Biological source: pigeon muscle (breast)

Properties

• biological source: pigeon muscle (breast)
• Quality Segment: 200
• assay: ≥95% based on Mol. Wt. 12,173 basis
• form: powder
• technique(s): cell culture | mammalian: suitable
• storage temp.: −20°C

Description

Application

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

Biochem/physiol Actions

The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen.

Preparation Note

Prepared with acetic acid without using TCA.

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)