C3652

5α-Cholest-7-en-3β-ol

• Synonym(s): 3β-Hydroxy-5α,7-cholestene, Lathosterol
• Empirical Formula (Hill Notation): C₂₇H₄₆O
• CAS Number: 80-99-9
• Molecular Weight: 386.65
• NACRES: NA.77
• PubChem Substance ID: 24892635
• UNSPSC Code: 12352211
• MDL number: MFCD00056176

Properties

• assay: ≥98% (TLC)
• Quality Segment: 200
• form: powder
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CC(CCC[C@@H](C)[C@@](CC[C@]1(C2=CC[C@@]3([H])C[C@@](O)(CC[C@]43C)[H])[H])([C@]1(CC[C@@]24[H])C)[H])C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21?,23?,24?,25?,26?,27?/m1/s1
• InChI key: IZVFFXVYBHFIHY-IRRCOBOTSA-N

Description

Application

5α-Cholest-7-en-3β-ol was used as a substrate in enzymatic assay for plasma cholesterol.[1] It was used to supplement diet of Daphnia galeata to study the effect on life-history traits.[2]

Biochem/physiol Actions

5α-Cholest-7-en-3β-ol (Lathosterol) is an intermediate in cholesterol biosynthesis pathway.[3] Lathosterol in serum is carried on lipoproteins and is indicative of the rate of cholesterol synthesis. It acts as a marker of synthesis of cholesterol and is not affected by dietary consumption of cholesterol.[4]

Preparation Note

5α-Cholest-7-en-3β-ol yields clear, colorless solution in chloroform at 10 mg/ml.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)