C0496

CRT0044876

≥98% (HPLC)

• Synonym(s): 7-Nitro-1H-indole-2-carboxylic acid, 7-Nitroindole-2carboxylic acid, NSC 69877
• Empirical Formula (Hill Notation): C₉H₆N₂O₄
• CAS Number: 6960-45-8
• Molecular Weight: 206.15
• NACRES: NA.25
• PubChem Substance ID: 329774800
• UNSPSC Code: 12352200
• EC Number: 230-154-6
• MDL number: MFCD00044720
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >20 mg/mL
• storage temp.: room temp
• SMILES string: OC(=O)c1cc2cccc([N+]([O-])=O)c2[nH]1
• InChI: 1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13)
• InChI key: BIUCOFQROHIAEO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CRT0044876 targets the APE1 active site and inhibits 3′-phosphodiesterase and 3′-phosphatase activities.

CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities—essential steps in excision repair—with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H319,H334
• pcodes: P261 - P264 - P280 - P284 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves