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B7652

Betamethasone 21-phosphate disodium

≥97%, glucocorticoid steroid, powder

Synonym(s):

Betamethasone disodium phosphate, Betamethasone sodium phosphate

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250 MG

$170.00

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$330.65

$170.00

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About This Item

Empirical Formula (Hill Notation):
C22H28FNa2O8P
CAS Number:
151-73-5
Molecular Weight:
516.40
NACRES:
NA.77
PubChem Substance ID:
24892013
UNSPSC Code:
12352200
EC Number:
205-797-0
MDL number:
MFCD00200361
Assay:
≥97%
Form:
powder
Quality level:
100

Key Documents

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Product Name

Betamethasone 21-phosphate disodium, ≥97%

sterility

non-sterile

Quality Level

100

assay

≥97%

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

InChI key

PLCQGRYPOISRTQ-LWCNAHDDSA-L

Gene Information

human ... NR3C1(2908)

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1 of 4

This Item
1068004B1045000S5136
Betamethasone 21-phosphate disodium ≥97%

Sigma-Aldrich

B7652

Betamethasone 21-phosphate disodium

Betamethasone sodium phosphate United States Pharmacopeia (USP) Reference Standard

USP

1068004

Betamethasone sodium phosphate

Betamethasone sodium phosphate European Pharmacopoeia (EP) Reference Standard

B1045000

Betamethasone sodium phosphate

Sodium phosphate dibasic BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99.0%

Sigma-Aldrich

S5136

Sodium phosphate dibasic

assay

≥97%

assay

-

assay

-

assay

≥99.0%

form

powder

form

-

form

-

form

powder or crystals

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

200

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

storage temp.

room temp

solubility

water: 50 mg/mL, clear to very slightly hazy, faintly yellow

solubility

-

solubility

-

solubility

water: soluble 100 mg/mL

shipped in

ambient

shipped in

-

shipped in

-

shipped in

-

General description

Betamethasone is a corticosteroid with anti-inflammatory and immunosuppressive abilities, used especially where water retention is undesirable. It is applied as a topical cream, ointment, lotion or gel to treat itching (e.g. from eczema). Corticosteroid used to stimulate fetal lung maturation and to decrease the incidence and mortality from intracranial hemorrhage in premature infants

Biochem/physiol Actions

Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B - STOT RE 2

target_organs

Liver,Kidney,Endocrine system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV7800
MKCQ4978
MKCK3324
MKBS9676V
SLBB0343V

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Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial
Dalziel SR, et al.
Lancet, 365(9474), 1856-1862 (2005)
Efficacy results of a 52-week, randomised, double-blind, safety study of a calcipotriol/betamethasone dipropionate two-compound product (Daivobet/Dovobet/Taclonex) in the treatment of psoriasis vulgaris
Kragballe K, et al.
Dermatology (Basel, Switzerland), 213(4), 319-326 (2006)
Tsutomu Ishihara et al.
International journal of pharmaceutics, 385(1-2), 170-175 (2009-10-20)
We have prepared polymeric nanoparticles using a blend of poly(lactic acid) and monomethoxy-polyethyleneglycol(PEG)-polylactide block copolymer along with betamethasone disodium phosphate (BP). Nanoparticles have been screened for anti-inflammatory activity using experimental rat models of inflammation. In the present study, we examined
Jun Lu et al.
Journal of chromatography. A, 1217(44), 6932-6941 (2010-09-22)
Betamethasone Sodium Phosphate and Betamethasone Acetate are the two corticosteroids active pharmaceutical ingredients (APIs) that are present in the injectable formulation, Celestone Chronodose(®) Injection. It is extremely challenging to develop a Quality Control friendly HPLC method to separate all the
Masatomo Kato et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 27(4), 353-360 (2011-05-18)
Glucocorticoids exert their actions via the glucocorticoid receptor through at least 2 intracellular mechanisms, known as transrepression and transactivation. It has been hypothesized that transrepression is the basis of their anti-inflammatory effects, whereas transactivation has been assumed to cause their
View All Related Papers

Global Trade Item Number

SKUGTIN
B7652-1G04061826232422
B7652-250MG04061838352712

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