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B0385

Beclomethasone

≥99%, anti-inflammatory agent, powder

Synonym(s):

9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione

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100 MG

$277.00

250 MG

$606.00

1 G

$1,650.00

$277.00

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About This Item

Empirical Formula (Hill Notation):
C22H29ClO5
CAS Number:
4419-39-0
Molecular Weight:
408.92
NACRES:
NA.77
PubChem Substance ID:
24278253
UNSPSC Code:
12352200
EC Number:
224-585-9
MDL number:
MFCD00135614
Assay:
≥99%
Form:
powder
Quality level:
100

Key Documents

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Product Name

Beclomethasone, ≥99%

Quality Level

100

assay

≥99%

form

powder

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

[H][C@]12C[C@@H](C)[C@@](O)(C(=O)CO)[C@]1(C)C[C@@H](O)[C@@]3(Cl)[C@]2([H])CCC4=CC(=O)C=C[C@@]34C

InChI

1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12?,15?,16?,17?,19?,20?,21-,22?/m0/s1

InChI key

NBMKJKDGKREAPL-WOOYFSPWSA-N

Gene Information

human ... CYP1A2(1544)

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1 of 4

This Item
B0515B7005D1756
Beclomethasone ≥99%

Sigma-Aldrich

B0385

Beclomethasone

Betamethasone 17-valerate

Sigma-Aldrich

B0515

Betamethasone 17-valerate

Betamethasone ≥98%

Sigma-Aldrich

B7005

Betamethasone

Dexamethasone ≥98% (HPLC), powder

Sigma-Aldrich

D1756

Dexamethasone

form

powder

form

powder

form

powder

form

powder

assay

≥99%

assay

-

assay

≥98%

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

originator

GlaxoSmithKline

originator

Schering Plough

originator

-

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

Gene Information

human ... CYP1A2(1544)

Gene Information

-

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Application

Beclomethasone has been used in MS−MS (mass spectrometry) methods for the analysis of β-agonists, corticosteroids, chloramphenicol and penicillins. It has also been used to find the differential response of glucocorticoids in larval regeneration model.

Biochem/physiol Actions

Beclomethasone is an anti-inflammatory glucocorticoid.
It helps to decrease airway hyperresponsiveness. It also helps to regulate symptoms of asthma.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX9731
MKCW1971
MKCW2001
MKCV4289
MKCV0784

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Lydia J Finney et al.
The Journal of allergy and clinical immunology, 147(2), 510-519 (2020-10-18)
The mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled corticosteroids (ICSs) are widely used in COPD, but the extent
A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers.
Paul Hagedoorn et al.
The journal of allergy and clinical immunology. In practice, 8(3), 1124-1125 (2019-10-09)
Yufei Xie et al.
Disease models & mechanisms, 12(5) (2019-05-11)
Glucocorticoid drugs are widely used to treat immune-related diseases, but their use is limited by side effects and by resistance, which especially occurs in macrophage-dominated diseases. In order to improve glucocorticoid therapies, more research is required into the mechanisms of
Hanna Valo et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 50(1), 69-77 (2013-03-19)
Highly porous nanocellulose aerogels prepared by freeze-drying from various nanofibrillar cellulose (NFC) hydrogels are introduced as nanoparticle reservoirs for oral drug delivery systems. Here we show that beclomethasone dipropionate (BDP) nanoparticles coated with amphiphilic hydrophobin proteins can be well integrated
Hong Ping Zhang et al.
Allergy and asthma proceedings, 35(4), 278-287 (2014-07-06)
It has proven efficacy in reducing asthma exacerbations, but the effect size of montelukast (a leukotriene receptor antagonist) for varied severity of asthma exacerbations is not systematically assessed. This study was designed to systematically explore the evidence for montelukast, as
View All Related Papers

Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Global Trade Item Number

SKUGTIN
B0385-1G04061833419755
B0385-100MG04061832630984
B0385-250MG04061833419762

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