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About This Item
Empirical Formula (Hill Notation):
C26H43NO2
CAS Number:
Molecular Weight:
401.63
UNSPSC Code:
12352204
PubChem Substance ID:
MDL number:
biological source
synthetic
assay
≥97.0% (HPLC)
form
crystals and lumps
storage temp.
2-8°C
SMILES string
CC(C)CNC(=O)[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C26H43NO2/c1-16(2)15-27-24(29)17(3)21-8-9-22-20-7-6-18-14-19(28)10-12-25(18,4)23(20)11-13-26(21,22)5/h7,16-19,21-23,28H,6,8-15H2,1-5H3,(H,27,29)/t17-,18-,19-,21+,22-,23-,25-,26+/m0/s1
InChI key
HUMXZYXRXDDZOG-LFZVSNMSSA-N
Biochem/physiol Actions
Lathosterolamide MGI-39 is an inhibitor of lathosterol oxidase which converts 5-α-cholest-7-en-3-β-ol to cholesta-5,7-dien-3β-ol. [1]
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Ralf Klingenstein et al.
Journal of neurochemistry, 98(3), 748-759 (2006-06-06)
Prion diseases are invariably fatal, neurodegenerative diseases transmitted by an infectious agent, PrPSc, a pathogenic, conformational isoform of the normal prion protein (PrPC). Heterocyclic compounds such as acridine derivatives like quinacrine abolish prion infectivity in a cell culture model of
Ken'ichi Hagiwara et al.
Biological & pharmaceutical bulletin, 30(4), 835-838 (2007-04-06)
In prion diseases, the normal cellular form of prion protein (PrP(C)) is converted into the disease-associated isoforms (PrP(Sc)) which accumulate in the infected tissues. Although the precise mechanism of this conversion remains unsolved, drugs of various categories have been reported
Carlos Fernández et al.
Journal of lipid research, 46(5), 920-929 (2005-02-03)
Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement, cholesterol is essential in cell proliferation and other cell processes. The aim of the present study was to elucidate the stringency