Reaction is faster than the time it takes to run the TLC
09658
Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate
≥98.0% (T)
Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate
Synonym(s):
TCFH
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 g | Check Cart for Availability | $157.00 |
About This Item
Empirical Formula (Hill Notation):
C5H12ClF6N2P
CAS Number:
Molecular Weight:
280.58
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
7896715
Assay:
≥98.0% (T)
Quality Segment
assay
≥98.0% (T)
reaction suitability
reaction type: Coupling Reactions
mp
99-112 °C
application(s)
peptide synthesis
storage temp.
2-8°C
SMILES string
F[P-](F)(F)(F)(F)F.CN(C)\C(Cl)=[N+](\C)C
InChI
1S/C5H12ClN2.F6P/c1-7(2)5(6)8(3)4;1-7(2,3,4,5)6/h1-4H3;/q+1;-1
InChI key
CUKNPSDEURGZCO-UHFFFAOYSA-N
Application
Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate can be used as a reactant for the synthesis of:
It can also be used as a reagent for the synthesis of:
- Onium salts for use in peptide coupling.
- Benzotriazole based uranium reagent, a safer replacement for coupling reagents.
It can also be used as a reagent for the synthesis of:
- Cancer cell cytotoxins.
- Bioconjugation reagents.
Other Notes
Coupling reagent for peptide synthesis and starting material for preparing other coupling reagents
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98.0% (T) | assay 97% | assay - | assay 96% |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| reaction suitability reaction type: Coupling Reactions | reaction suitability reaction type: Coupling Reactions | reaction suitability - | reaction suitability - |
| mp 99-112 °C | mp 104-109 °C (lit.) | mp 14-18 °C (lit.) | mp 171-177 °C |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
| application(s) peptide synthesis | application(s) peptide synthesis | application(s) - | application(s) - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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N, N, N′, N′-Tetramethylchloroformamidinium hexafluorophosphate (TCFH), a powerful coupling reagent for bioconjugation
Tulla-Puche J, et al.
Bioconjugate Chemistry, 19(10), 1968-1971 (2008)
J. Habermann et al.
J. Prakt. Chem./Chem.-Ztg., 340, 233-233 (1998)
TCFH?NMI: Direct Access to N-Acyl Imidazoliums for Challenging Amide Bond Formations
Beutner, Gregory et. al.
Organic Letters, 20(14), 4218?4222-4218?4222 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 235857-25G | 04061838785275 |
| 235857-100G | 04061838785268 |
| 8180970050 | 04022536427515 |
| 09658-5G | 04061833354896 |