SCC700

3dGRO^® Pancreatic Organoids (PPTO.02)

Ductal Adenocarcinoma, Pancreas, Age: 62, Male, Mutation: KRAS G12D

• Synonym(s): Pancreatic Cancer Organoid;PDAC Organoid;Pancreatic Tumor Organoid;Pancreatic Ductal Organoid, human organoids, pancreas organoids
• NACRES: NA.21
• UNSPSC Code: 41106514

Properties

• Quality Level: 100
• biological source: human pancreas
• packaging: vial of ≥1500 organoids vials
• manufacturer/tradename: Millipore
• gender: male
• technique(s): cell culture: suitable
• application(s): 3D cell culture
• control: pancreas
• relevant disease(s): adenocardinoma (ductal)
• shipped in: liquid nitrogen
• storage temp.: −196°C

Description

General description

The pancreas is both an endocrine and exocrine organ that plays role in digestion and metabolic homeostasis. Endocrine compartments include the alpha and beta cells which secrete the hormones glucagon and insulin and exocrine compartment including acinar cells, which store and secrete digestive enzymes and highly branched, tubular epithelial tree–like ductal networks. Pancreatic ductal adenocarcinoma (PDACs) is one of the most lethal forms of cancer with 5-year survival rates less than 8% and is projected to be the second most common cause of cancer-related deaths by 2030. Recent breakthroughs in three-dimensional (3D) culture methods have led to the development of organoid culture platforms, which allow researchers to perform translational research on long-term in vitro cultures not limited by barriers present in 2D culture or animal models. We now offer a comprehensive collection of patient derived pancreatic ductal adenocarcinoma cancer (PDAC) organoids for cancer research and drug discovery applications.

Cell Line Characteristics

• Sex: Male
• Age: 62 Years
• Organ: Pancreas (Primary Tumor)
• Disease: Ductal Adenocarcinoma (KRAS mutation: G12D)

Application

• Viability: >1500 viable organoids/vial
• Organoid Growth: Pass
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Mycoplasma Contamination: Negative
• STR Profile: Pass

Features and Benefits

Cryopreserved patient derived pancreatic cancer organoids (PDOs)

Preparation Note

Store in liquid nitrogen. The organoids can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Legal Information

3dGRO^® is a trademark of Merck KGaA, Darmstadt, Germany.
3dGRO^® organoids were derived utilizing HUB Organoid Technology.

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/pdouse. This product may not be re-engineered or copied; used to make derivatives or modifications; used to develop, test, or manufacture a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact [email protected].

3dGRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable