MABC598

Anti-PACS2 Antibody, clone 9F12.2

clone 9F12.2, from mouse

• Synonym(s): Phosphofurin acidic cluster sorting protein 2, PACS1-like protein, PACS2
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: 9F12.2, monoclonal
• Application: WB
• Citations: -

Properties

• biological source: mouse
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 9F12.2, monoclonal
• species reactivity: mouse, rat
• technique(s): western blot: suitable
• isotype: IgG1κ
• NCBI accession no.: NP_001094383
• UniProt accession no.: Q86VP3
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: mouse ... Pacs2(217893)

Description

General description

Phosphofurin acidic cluster sorting protein 2 (PACS2), also known as PACS-2, PACS1-like protein, and encoded by the gene name PACS2/ KIAA0602/ PACS1L, is a amember of the PACS family. PACS2 is a multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Additionally, PACS2 translocates BIB to mitochondria in response to apoptic inducers, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome C, and the activation of caspase-3 thereby causing cell death. Recent studies have indicated that PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. PACS2 interacts with BID, PKD2, and HIV-1 Nef.

~100 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to Human PACS2.

Application

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-PACS2 antibody is validated for use in Western Blotting for the detection of PACS2.

Western Blotting Analysis: A 1:500 dilution from a representative lot detected PACS2 in 10 µg of mouse hypothalamus tissue.

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Evaluated by Western Blotting in rat hippocampus tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PACS2 in 10 µg of rat hippocampus tissue lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable