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5.08773

PPACK, 2HCl

InSolution, ≥88%

Synonym(s):

InSolution PPACK, 2HCl, D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone, 2HCl, H-D-Phe-Pro-Arg-chloromethylketone, 2HCl, PPACK, dihydrochloride InSolution

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Pack SizeSKUAvailabilityPrice
5 mg
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$253.00

About This Item

Empirical Formula (Hill Notation):
C21H31ClN6O3 · 2HCl
Molecular Weight:
523.88
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥88% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, protect from light

$253.00

Check Cart for Availability
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Quality Level

100

assay

≥88% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

storage temp.

−70°C

General description

D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK) is a potent and specific inhibitor of thrombin with ideal, unbiased properties for use as an anticoagulant in blood gas, electrolyte, and iCa analyses.[1]

Biochem/physiol Actions

Reversible: no

Packaging

Packaged under inert gas

Physical form

A 25 mM (5 mg/357 µl) sterile-filtered solution of PPACK, 2HCl (Cat. No. 520222) in H₂O.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Rosado, J. A., et al. 2002. J. Biol. Chem.277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry32, 4727.
Yamashita, T., et al. 1993. Thromb. Res.69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.

Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
066655202225.08436
PPACK, 2HCl InSolution, ≥88%

Sigma-Aldrich

5.08773

PPACK, 2HCl

(S)-trans-2-Amino-4-(2-aminoethoxy)-3-butenoic acid hydrochloride ≥93% (AT)

Sigma-Aldrich

06665

(S)-trans-2-Amino-4-(2-aminoethoxy)-3-butenoic acid hydrochloride

PPACK, Dihydrochloride PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry.

Sigma-Aldrich

520222

PPACK, Dihydrochloride

AEBSF Hydrochloride InSolution, ≥97%, Specific, irreversible inhibitor of serine proteases

Sigma-Aldrich

5.08436

AEBSF Hydrochloride

assay

≥88% (HPLC)

assay

≥93% (AT)

assay

≥80% (HPLC)

assay

≥97% (HPLC)

form

liquid

form

powder

form

solid

form

liquid

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−70°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−70°C

storage condition

OK to freeze, protect from light, avoid repeated freeze/thaw cycles

storage condition

-

storage condition

OK to freeze, desiccated, protect from light

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

does not flash

flash_point_c

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M E Lyon et al.
Clinical chemistry, 41(7), 1038-1041 (1995-07-01)
D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK), a selective thrombin inhibitor, was evaluated as an alternative anticoagulant to lithium heparin (LiHep) for blood gas and whole-blood electrolyte analyses. Initial studies in serum revealed a negative proportional bias for ionized calcium (iCa) concentration measured

Global Trade Item Number

SKUGTIN
508773000104055977261394

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