324694

Emodin

A cell-permeable, reversible, substrate competitive and potent p56^lck tyrosine kinase inhibitor (IC₅₀ = 18.5 µM).

• Synonym(s): Emodin, 6-Methyl-1,3,8-trihydroxyanthraquinone
• Empirical Formula (Hill Notation): C₁₅H₁₀O₅
• CAS Number: 518-82-1
• Molecular Weight: 270.24
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00001207
• Assay: ≥90% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Properties

• Quality Segment: 100
• description: Merck USA index - 14, 3561
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: orange
• solubility: DMSO: 1 mg/mL, aqueous base: soluble, ethanol: soluble
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Oc1c2c(cc(c1)O)C(=O)c3c(c(cc(c3)C)O)C2=O
• InChI: 1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
• InChI key: RHMXXJGYXNZAPX-UHFFFAOYSA-N

Description

General description

A cell-permeable, reversible, substrate competitive and potent p56^lck tyrosine kinase inhibitor (IC₅₀ = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC₅₀ = 14.8 µM) without affecting normal human bronchial epithelial cells, even at a concentration of 370 mM. Reported to act as an inhibitor of Tau aggregation and aid in the disassembly of PHF in vitro and in vivo.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
p56^lck tyrosine kinase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 18.5 µM against p56lck tyrosine kinase

Preparation Note

Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.

Other Notes

Pickhardt, M., et al. 2004. J. Biol. Chem.280, 3628.
Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
Jayasuriya, H., et al. 1992. J. Nat. Prod.55, 696.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable