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239807

Cyclopamine-KAAD

≥70% (sum of two isomers, HPLC), liquid, Hedgehog signaling inhibitor, Calbiochem®

Synonym(s):

3- Keto-N-( aminoethyl- aminocaproyl- dihydrocinnamoyl)cyclopamine, 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, InSolution Cyclopamine-KAAD

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Pack SizeSKUAvailabilityPrice
50 μg
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$190.00

About This Item

UNSPSC Code:
12352116
NACRES:
NA.77
Assay:
≥70% (sum of two isomers, HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

$190.00

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Product Name

Cyclopamine-KAAD, InSolution, ≥70%, inhibits Hedgehog (Hh) signaling

Quality Level

100

assay

≥70% (sum of two isomers, HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

shipped in

dry ice

storage temp.

−70°C

General description

A cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239803) is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
SmoA1

Packaging

Packaged under inert gas

Physical form

A 1 mM (50 µg/72 µL) solution of Cyclopamine-KAAD (Cat. No. 239804) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Other Notes

Siegelin, M.D. et al. 2009. Neurobiol. Dis.34, 259.
Watkins, D.N., et al. 2003. Nature422, 313.
Berman, D.M., et al. 2002. Science297, 1559.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Chen, J.K., et al. 2002. Genes Dev.16, 2743.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.
Taipale, J., et al. 2000. Nature406, 1005.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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This Item
239804260964373270
Cyclopamine-KAAD InSolution, ≥70%, inhibits Hedgehog (Hh) signaling

Sigma-Aldrich

239807

Cyclopamine-KAAD

Cyclopamine-KAAD Cyclopamine- KAAD, CAS 306387-90-6, is a cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM).

Sigma-Aldrich

239804

Cyclopamine-KAAD

DNA-PK Inhibitor V The DNA-PK Inhibitor V, also referenced under CAS 404009-46-7, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

260964

DNA-PK Inhibitor V

Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 The Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1, also referenced under CAS 313553-47-8, controls the biological activity of Hec1/Nek2 Mitotic Pathway.

Sigma-Aldrich

373270

Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1

form

liquid

form

solid

form

solid

form

solid

assay

≥70% (sum of two isomers, HPLC)

assay

≥70% (sum of two isomers, HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−70°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, desiccated (hygroscopic), avoid repeated freeze/thaw cycles, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (refers to pure substance)

flash_point_c

87 °C - closed cup - (refers to pure substance)

Certificates of Analysis (COA)

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Betty R Lawton et al.
Endocrinology, 161(10) (2020-08-19)
Differentiation of pluripotent stem cells into functional parathyroid-like cells would accelerate development of important therapeutic options for subjects with parathyroid-related disorders, from the design and screening of novel pharmaceutical agents to the development of durable cellular therapies. We have established

Global Trade Item Number

SKUGTIN
239807-50UG04055977198928

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