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Carbonyl Cyanide m-Chlorophenylhydrazone

Name: Carbonyl Cyanide <i>m</i>-Chlorophenylhydrazone
Brand: MM
Price: 144 USD
Availability: InStock

≥95% (HPLC), solid, mitophagy inducer, Calbiochem

Synonym(s):

Carbonyl Cyanide m-Chlorophenylhydrazone, CCCP

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Pack Size	SKU	Availability	Price
250 mg		Check Cart for Availability	$144.00

About This Item

CAS Number:

555-60-2

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00001848

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze

$144.00

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Properties

Product Name

Carbonyl Cyanide m-Chlorophenylhydrazone, Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol.

Quality Segment

100

description

RTECS - FG5600000

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

yellow

solubility

ethanol: 1 mg/mL, DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Clc1cc(ccc1)NN=C(C#N)C#N

InChI

1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H

InChI key

UGTJLJZQQFGTJD-UHFFFAOYSA-N

Description

General description

Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol. Binds with cytochrome c oxidase with high affinity (K_d = 270 nM). Inhibits transport processes and depresses growth.

Biochem/physiol Actions

Cell permeable: no

Kd = 270 nM in binding with cytochrome c oxidase

Primary Target
cytochrome c oxydase

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.

Other Notes

Bona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun.7, 272.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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This Item	390238	C2759	499610
Sigma-Aldrich 215911 Carbonyl Cyanide m-Chlorophenylhydrazone	Sigma-Aldrich 390238 Camptothecin, 10-Hydroxy-, Camptotheca acuminata	Sigma-Aldrich C2759 Carbonyl cyanide 3-chlorophenylhydrazone	Sigma-Aldrich 499610 (5Z)-7-Oxozeaenol, Curvularia sp.
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥97% (TLC)	assay ≥95% (HPLC)
form solid	form powder	form powder	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
solubility ethanol: 1 mg/mL, DMSO: 5 mg/mL	solubility DMSO: 5 mg/mL	solubility DMSO: 100 mM	solubility DMSO: 10 mg/mL, ethanol: 5 mg/mL

pictograms

GHS06

signalword

Danger

hcodes

H301 + H311 + H331,H315,H319,H335

pcodes

P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Certificates of Analysis (COA)

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Global Trade Item Number

SKU	GTIN
215911-250MG	04055977219241

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