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189482

Autocamtide-2 Related Inhibitory Peptide, Myristoylated

≥97% (HPLC), CaM kinase II inhibitor, lyophilized

Synonym(s):

Autocamtide-2 Related Inhibitory Peptide, Myristoylated, Myristoylated AIP, Myr-N-KKALRRQGAVDAL-OH

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Size/SKUAvailabilityPrice
500 μg
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$300.00

About This Item

Empirical Formula (Hill Notation):
C78H142N22O20
Molecular Weight:
1708.10
UNSPSC Code:
12352202
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
lyophilized
Storage condition:
OK to freeze, desiccated (hygroscopic)

$300.00

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Product Name

Autocamtide-2 Related Inhibitory Peptide, Myristoylated, The Autocamtide-2 Related Inhibitory Peptide, Myristoylated controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Quality Segment

100

assay

≥97% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

This peptide corresponds to AIP (Cat. No. 189480 ) which has been myristoylated at the N-terminus, thus enhancing its cell-permeability.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Calmodulin-Dependent Protein Kinase (CaM Kinase)-2
Product does not compete with ATP.
Reversible: no
Target IC50: 40 nM against cam Kinase-2

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gailly, P., et al. 1998. Cell Calcium 24, 293.
Ishida, A., and Fujisawa, H. 1995. J. Biol. Chem.270, 2163.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun.212, 806.
Myr-N-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
208921476485189485
Autocamtide-2 Related Inhibitory Peptide, Myristoylated The Autocamtide-2 Related Inhibitory Peptide, Myristoylated controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

189482

Autocamtide-2 Related Inhibitory Peptide, Myristoylated

Calmodulin Kinase IINtide, Myristoylated The myristoylated form of CaMK IINtide.

Sigma-Aldrich

208921

Calmodulin Kinase IINtide, Myristoylated

PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated PKA Inhibitor 14-22 Amide is myristoylated at the N-terminus that enhances its cell-permeability. The non-myristoylated version is shown to be a specific inhibitor of PKA (Ki = 36 nM).

Sigma-Aldrich

476485

PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable The Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

189485

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

form

lyophilized

form

solid

form

lyophilized

form

lyophilized solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: 1 mg/mL

solubility

DMSO: 5 mg/mL

solubility

water: 1 mg/mL

solubility

5% acetic acid: 1 mg/mL, water: 1 mg/mL, DMSO: 5 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Questions

  1. Do you send with the negative control (scramble sequence) ? How are we ordering scramble sequence?

    1 answer

    1. This product does not include a negative control (scramble sequence). Currently, no such negative control is available.

      Please see the Custom Peptide Synthesis at the link below:
      https://www.sigmaaldrich.com/technical-documents/technical-article/protein-biology/protein-and-nucleic-acid-interactions/custom-peptides

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