1.01115

Ammonium acetate

EMPLURA^®

• Synonym(s): Ammonium acetate
• Empirical Formula (Hill Notation): C₂H₇NO₂
• CAS Number: 631-61-8
• Molecular Weight: 77.08
• UNSPSC Code: 12352107
• EC Index Number: 211-162-9
• NACRES: NA.21
• MDL number: MFCD00013066
• Assay: ≥96.0% (alkalimetric)
• Form: solid
• Solubility: 1480 g/L

Properties

• Quality Segment: 200
• product line: EMPLURA^®
• assay: ≥96.0% (alkalimetric)
• form: solid
• ign. residue: ≤0.02% (as sulfate)
• pH: 6.7-7.3 (25 °C, 50 g/L in H₂O)
• mp: 114 °C
• solubility: 1480 g/L
• density: 1.17 g/cm³ at 20 °C
• bulk density: 410 kg/m³
• anion traces: chloride (Cl^-): ≤0.002%, sulfate (SO₄^2-): ≤0.01%
• cation traces: Fe: ≤0.001%, heavy metals (as Pb): ≤0.0005%
• storage temp.: 15-25°C
• SMILES string: [NH4]OC(=O)C
• InChI: 1S/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3
• InChI key: USFZMSVCRYTOJT-UHFFFAOYSA-N

Description

Application

• One-Pot, Four-Component Reaction for the Design, Synthesis, and SAR Studies of Novel Pyridines for Insecticidal Bioefficacy Screening against Cowpea Aphid (Aphis craccivora): This study explores the application of ammonium acetate in facilitating the synthesis of novel pyridine derivatives, evaluated for their insecticidal properties against Aphis craccivora (Alkorbi et al., 2024).


• A green analytical method for the simultaneous determination of 17 perfluoroalkyl substances (PFAS) in human serum and semen by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS): This research demonstrates the use of ammonium acetate in UPLC-MS/MS for detecting PFAS in biological samples, highlighting its role in environmental and health-related analytical chemistry (Di Giorgi et al., 2024).


• Innovation of 6-sulfonamide-2H-chromene derivatives as antidiabetic agents targeting α-amylase, α-glycosidase, and PPAR-γ inhibitors with in silico molecular docking simulation: Ammonium acetate was utilized in the synthesis process of new chromene derivatives, showing potential as antidiabetic agents by inhibiting α-amylase and α-glycosidase activities (Thabet et al., 2024).


• Regulation of Tetramethylpyrazine Formation by the Phenolics-Fenton Coupled Redox Cycling System: This article presents a study on the role of ammonium acetate in the formation of tetramethylpyrazine via redox cycling, an important reaction in food chemistry and possibly in synthesizing complex organic molecules (Xu et al., 2024).


• Simultaneous determination of unecritinib (TQ-B3101) and its active metabolite crizotinib in rat plasma by LC-MS/MS: An application to pharmacokinetic studies: This paper details the use of ammonium acetate in enhancing LC-MS/MS methodologies for pharmacokinetic studies, exemplifying its critical role in the analysis of pharmaceutical compounds (Wang et al., 2024).

Analysis Note

Assay (alkalimetric): ≥ 96.0 %
Identity: passes test
pH-value (5 %; water): 6.0 - 7.5
Chloride (Cl): ≤ 0.002 %
Sulfate (SO₄): ≤ 0.01 %
Heavy metals (as Pb): ≤ 0.0005 %
Fe (Iron): ≤ 0.001 %
Residue on ignition (as sulfate): ≤ 0.02 %
Water: ≤ 2.5 %

Legal Information

EMPLURA is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable