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09-409

Anti-SUMO-1 Antibody

Upstate®, from rabbit

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100 μL
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$541.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
7

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity (predicted by homology)

all

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_001005781.1, NM_001005782.1, NM_003352.4

UniProt accession no.

P63165

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SENP2(59343), SUMO1(7341)

General description

The small ubiquitin-related modifier SUMO-1 belongs to the growing family of ubiquitin-related proteins involved in post translational protein modification1. It is present in all eukaryotic kingdoms and is highly conserved from yeast to humans. SUMO-1 does not appear to target proteins for degradation but seems to be involved in the modulation of protein-protein interactions. An increasing number of SUMO-1 substrates are being described but three major substrates for SUMO-1 modification are RanGAP1 and PML proteins.

Immunogen

Synthetic peptide corresponding to amino acid residues 11-101 of human SUMO-1.

Application

Anti-SUMO-1 Antibody detects level of SUMO-1 & has been published & validated for use in WB.

Biochem/physiol Actions

Recognizes SUMO-1. This antibody shows no cross-reactivity with ubiquitin, multi-ubiquitin chains, SUMO2/3, UCRP, Nedd8, and FAT10.

Physical form

100 µL of purified by salt precipitation in PBS containing 0.01% sodium azide. Dilute to working strength with 50mM Tris-HCl buffer (pH 7.6) containing 1.5% sodium chloride and 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used).
Format: Purified

Other Notes

Replaces: 04-453

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Anti-SUMO-1 Antibody Upstate®, from rabbit

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Sigma-Aldrich

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Anti-SUMO 2/3 Antibody

Anti-Drosophila Sumo (C-term) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution

Sigma-Aldrich

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Anti-Drosophila Sumo (C-term) antibody produced in rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified antibody

antibody form

purified from hybridoma cell culture

antibody form

-

antibody form

IgG fraction of antiserum

clone

polyclonal

clone

4D12, monoclonal

clone

polyclonal

clone

polyclonal

biological source

rabbit

biological source

rat

biological source

rabbit

biological source

rabbit

technique(s)

western blot: suitable

technique(s)

immunocytochemistry: suitable, western blot: suitable

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

indirect ELISA: 1:1000, western blot: 1:100-1:500

Gene Information

human ... SENP2(59343), SUMO1(7341)

Gene Information

human ... SUMO1(7341)

Gene Information

human ... SUMO2(6613)
mouse ... Sumo2(170930)
opossum ... Sumo2(123244757)
rat ... Sumo2(690244)

Gene Information

human ... SUMO1(7341)

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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

12 - Non Combustible Liquids

Certificates of Analysis (COA)

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P Bayer et al.
Journal of molecular biology, 280(2), 275-286 (1998-07-09)
The recently discovered small ubiquitin-related modifier SUMO-1 belongs to the growing family of ubiquitin-related proteins involved in postranslational protein modification. Unlike ubiquitin, SUMO-1 does not appear to target proteins for degradation but seems to be involved in the modulation of
C Kretz-Remy et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 77(4), 299-309 (1999-11-05)
Regulation of protein functions can be achieved by posttranslational protein modifications. One of the most studied modifications has been conjugation to ubiquitin, which mainly targets substrate proteins for degradation by the 26 S proteasome. Recently, SUMO/sentrin, a ubiquitin-like protein has
Lorna Moll et al.
eLife, 7 (2018-11-08)
Although aging-regulating pathways were discovered a few decades ago, it is not entirely clear how their activities are orchestrated, to govern lifespan and proteostasis at the organismal level. Here, we utilized the nematode Caenorhabditis elegans to examine whether the alteration
View All Related Papers

Global Trade Item Number

SKUGTIN
09-40904053252337758

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