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Anti-phospho-STAT1 (Ser 727) Antibody, clone 12C5

Name: Anti-phospho-STAT1 (Ser 727) Antibody, clone 12C5
Brand: MM
Price: 490 USD

clone 12C5, Upstate^®, from mouse

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Pack Size	SKU	Availability	Price
100 μg		Check Cart for Availability	$490.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Clone:

12C5, monoclonal

Species reactivity:

human

Application:

ELISA, WB

Citations:

$490.00

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Properties

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

12C5, monoclonal

species reactivity

human

manufacturer/tradename

Upstate^®

technique(s)

ELISA: suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

NM_007315.2, NM_139266.1

UniProt accession no.

P42224

shipped in

wet ice

target post-translational modification

phosphorylation (pSer727)

Gene Information

human ... STAT1(6772)

Description

General description

92 kDa

Immunogen

KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Serine727 on phosphorylated STAT1

Application

Anti-phospho-STAT1 (Ser 727) Antibody, clone 12C5 is a Mouse Monoclonal Antibody for detection of phospho-STAT1 (Ser 727) also known as signal transducer & activator of transcription 1 & has been tested in ELISA & WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Biochem/physiol Actions

Recognizes phosphorylated domain of STAT1 on Serine727

Physical form

Format: Purified

In 1 mL of PBS containing 0.09% sodium azide, PEG, sucrose, and 50% glycerol.

Subsequent thiophilic adsorption and size exclusion chromatography

Preparation Note

2 years at -20°C from date of shipment. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Analysis Note

Routinely evaluated by immunoblot.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	05-590	SAB5700330	SAB5701841
Sigma-Aldrich 04-478 Anti-phospho-STAT1 (Ser 727) Antibody, clone 12C5	Sigma-Aldrich 05-590 Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12	Sigma-Aldrich SAB5700330 Anti-Phospho-STAT1-S727 antibody produced in rabbit	Sigma-Aldrich SAB5701841 Anti-Phospho-STAT1-S727 antibody produced in rabbit
biological source mouse	biological source mouse	biological source rabbit	biological source rabbit
clone 12C5, monoclonal	clone 16E12, monoclonal	clone polyclonal	clone monoclonal
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form -
species reactivity human	species reactivity human, mouse, rat	species reactivity mouse, human, rat	species reactivity human
technique(s) ELISA: suitable, western blot: suitable	technique(s) western blot: suitable	technique(s) immunohistochemistry: 1:50-1:100, immunoprecipitation (IP): 1:50-1:100, western blot: 1:500-1:2000	technique(s) western blot: 1:500-1:2000
UniProt accession no. P42224	UniProt accession no. P42226	UniProt accession no. P42224	UniProt accession no. P42224

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Storage Class

10 - Combustible liquids

wgk

WGK 2

Certificates of Analysis (COA)

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Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK.

Rico K H Lo et al.

Cellular signalling, 18(3), 307-317 (2005-06-28)

The ability of the human prostacyclin receptor (hIP) to regulate the activities of signal transducers and activators of transcription (STATs) has not yet been documented. In the present study, we have delineated the mechanism by which hIP induces STAT3 phosphorylations

VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance.

Lee, Y K, et al.

Leukemia, 19, 513-523 (2005)

Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression.

H Nguyen et al.

The Journal of biological chemistry, 276(36), 33361-33368 (2001-07-05)

STAT1 must be phosphorylated on serine 727 to be fully active in transcription. We show that phosphatidylinositol 3-kinase (PI3K) and its effector kinase Akt play an important role in the serine phosphorylation of STAT1 and in the activation of gene

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Global Trade Item Number

SKU	GTIN
04-478	04053252409615

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