04-145

Anti-NOD2 Antibody, clone 2D9

clone 2D9, from mouse

• Synonym(s): Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NLR family, CARD domain containing 2, NOD-like receptor C2, caspase recruitment domain family, member 15, caspase recruitment domain protein 15, nucleotide-binding ol
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: 2D9, monoclonal
• Application: IHC, IP, WB
• Citations: 1

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 2D9, monoclonal
• species reactivity: human
• technique(s): immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
• isotype: IgG1κ
• NCBI accession no.: NP_071445
• UniProt accession no.: Q9HC29
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... NOD2(64127)

Description

General description

NOD2 (nucleotide-binding oligomerization domain containing 2), also known as the caspase recruitment domain family, member 15 (CARD15), is a member of the NOD-like Receptor (NLR) family of proteins and plays an important role in the immune system. It is an intracellular pattern recognition receptor and is linked to inflammatory diseases such as inflammatory bowel disease/Crohn′s Disease and Blau syndrome. NOD2 has two caspase recruitment domains (CARDs) and eleven leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response by recognizing the bacterial molecules. Recently it is has been found to interact with NLRC4 and bind to MAVS in response to ssRNA or viral RNA treatment and activate the IFN response.

~110 kDa

Immunogen

Epitope: Unknown

His-tagged recombinant protein corresponding to human NOD2.

Application

Anti-NOD2 Antibody, clone 2D9 is a Mouse Monoclonal Antibody for detection of NOD2 also known as NOD-like receptor C2 & has been validated in IHC, WB & IP.

Research Category
Inflammation & Immunology

Research Sub Category
Immunological Signaling

Biochem/physiol Actions

This antibody recognizes NOD2.

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Hyperplastic colorectal carcinoma tissue

Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected NOD2 in hyperplastic colorectal carcinoma tissue.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable