Skip to Content
MilliporeSigma

Skip To

03-308

Magna ChIRP® NEAT1 lncRNA Probe Set

The Magna ChIRP NEAT1 lncRNA Probe Set contains 33 predesigned 20-mer DNA oligonucleotides tiled along and complementary to the sequence of human lncRNA NEAT1.

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
1 set
Check Cart for Availability
$336.00

About This Item

UNSPSC Code:
12161503
NACRES:
NA.52
eCl@ss:
32161000

$336.00


Check Cart for Availability

Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

manufacturer/tradename

Magna ChIRP®

technique(s)

DNA sequencing: suitable, RNA extraction: suitable (nuclear function kit), RNA purification: suitable (with magnetic beads), activity assay: suitable (protein interaction), nucleic acid detection: suitable (RNA), protein purification: suitable (protein determination)

shipped in

dry ice

General description

ChIRP (Chromatin Isolation by RNA Purification), allows recovery of specific segments of DNA and proteins using chromatin associated RNA as a target for biotinylated antisense probes. The Magna ChIRP NEAT1 lncRNA Probe Set contains 33 predesigned 20-mer DNA oligonucleotides tiled along and complementary to the sequence of human lncRNA NEAT1. All probes are biotin-TEG-labeled at the 3-prime end. The oligonucleotides are split to two pools (even and odd) and are supplied ready for use in the ChIRP method. This probe set is fully compatible with the Maga ChIRP kits (cat. # 17-10494 and 17-10495).

Application

Research Category
Epigenetics & Nuclear Function
The Magna ChIRP NEAT1 lncRNA Probe Set contains 33 predesigned 20-mer DNA oligonucleotides tiled along and complementary to the sequence of human lncRNA NEAT1.

Physical form

50 µM biotin-TEG-labeled 20-mer DNA oligonucleotides in containing 10 mM Tris-HCl, 1mM EDTA, pH 8.0

Preparation Note

Upon receipt store at -20°C. Avoid multiple freeze thaws. With proper storage and handling this product is stable for 6 months from the date of receipt.

Legal Information

MAGNA CHIRP is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
03-314-M03-312M03-313M
technique(s)

DNA sequencing: suitable, RNA purification: suitable (with magnetic beads), nucleic acid detection: suitable (RNA), RNA extraction: suitable (nuclear function kit), protein purification: suitable (protein determination), activity assay: suitable (protein interaction)

technique(s)

DNA sequencing: suitable, RNA extraction: suitable (nuclear function kit), RNA purification: suitable (with magnetic beads), activity assay: suitable (protein interaction), nucleic acid detection: suitable (RNA)

technique(s)

DNA sequencing: suitable, RNA extraction: suitable (nuclear function kit), RNA purification: suitable (with magnetic beads), activity assay: suitable (protein interaction), protein purification: suitable (protein determination)

technique(s)

DNA sequencing: suitable, RNA extraction: suitable (nuclear function kit), RNA purification: suitable (with magnetic beads), activity assay: suitable (protein interaction), nucleic acid detection: suitable (RNA), protein purification: suitable (protein determination)

manufacturer/tradename

Magna ChIRP®

manufacturer/tradename

Magna ChIRP®

manufacturer/tradename

Chemicon®, Magna ChIRP®

manufacturer/tradename

Chemicon®, Magna ChIRP®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

shipped in

dry ice

shipped in

-

shipped in

-

shipped in

-


Storage Class

10 - Combustible liquids



Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library


Related Content

Historically chromatin was considered to contain only DNA, histones, non-histone proteins and transiently associated mRNAs. While this remains true, current data suggest that a variety of non-coding RNAs (e.g. long non-coding RNAs, enhancer RNAs and even miRNAs) also associate with chromatin and serve regulatory functions.

Cancer is a complex disease manifestation. At its core, it remains a disease of abnormal cellular proliferation and inappropriate gene expression. In the early days, carcinogenesis was viewed simply as resulting from a collection of genetic mutations that altered the gene expression of key oncogenic genes or tumor suppressor genes leading to uncontrolled growth and disease (Virani, S et al 2012). Today, however, research is showing that carcinogenesis results from the successive accumulation of heritable genetic and epigenetic changes. Moreover, the success in how we predict, treat and overcome cancer will likely involve not only understanding the consequences of direct genetic changes that can cause cancer, but also how the epigenetic and environmental changes cause cancer (Johnson C et al 2015; Waldmann T et al 2013). Epigenetics is the study of heritable gene expression as it relates to changes in DNA structure that are not tied to changes in DNA sequence but, instead, are tied to how the nucleic acid material is read or processed via the myriad of protein-protein, protein-nucleic acid, and nucleic acid-nucleic acid interactions that ultimately manifest themselves into a specific expression phenotype (Ngai SC et al 2012, Johnson C et al 2015). This review will discuss some of the principal aspects of epigenetic research and how they relate to our current understanding of carcinogenesis. Because epigenetics affects phenotype and changes in epigenetics are thought to be key to environmental adaptability and thus may in fact be reversed or manipulated, understanding the integration of experimental and epidemiologic science surrounding cancer and its many manifestations should lead to more effective cancer prognostics as well as treatments (Virani S et al 2012).

View All Related Content





Global Trade Item Number

SKUGTIN
03-30804055977123548

Questions

Reviews

No rating value

Active Filters