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Merck

Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.

Journal of medicinal chemistry (2013-03-26)
Raffaele Pasceri, David Siegel, David Ross, Christopher J Moody
ABSTRAKT

A range of 2-aminophenoxazin-3-ones has been prepared by oxidative cyclocondensation of 2-aminophenols, including the natural products exfoliazone and chandrananimycin A, both synthesized for the first time. The compounds were evaluated for their ability to inhibit indoleamine 2,3-dioxygenase. Compounds containing additional electron-withdrawing carboxylate groups, such as cinnabarinic acid, showed modest inhibitory activity with a dose response.

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Sigma-Aldrich
Cinnabarinic Acid, ≥98% (HPLC)
Sigma-Aldrich
2-Aminophenol, 99%