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Informacje o tej pozycji
Wzór liniowy:
HSCH2CH(NHCOCH3)CO2H
Numer CAS:
Masa cząsteczkowa:
163.19
UNSPSC Code:
12352209
PubChem Substance ID:
EC Number:
210-498-3
Beilstein/REAXYS Number:
1724426
MDL number:
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Pozwól nam pomócNazwa produktu
N-Acetyl-L-cysteine, Vetec™, reagent grade, 98%
grade
reagent grade
product line
Vetec™
assay
98%
form
powder
color
white to off-white
mp
106-108 °C (lit.)
application(s)
cell analysis
storage temp.
2-8°C
SMILES string
CC(=O)N[C@@H](CS)C(O)=O
InChI
1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
InChI key
PWKSKIMOESPYIA-BYPYZUCNSA-N
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Application
- Antioxidant Assay Development: N-Acetyl-L-cysteine (NAC) is used in the metabolic activation and assessment of cytotoxicity of gramine mediated by CYP3A, showcasing its importance in biochemical assays that measure oxidative stress, a critical factor in IVD reagent development (Gao et al., 2024).
- Cell Differentiation and NF-κB Inhibition: NAC′s role extends to inducing oxidative stress and inhibiting NF-κB pathways, which is crucial for the differentiation of cells in AML treatment. This application demonstrates NAC′s utility in clinical diagnostic reagents aimed at cancer treatment and research (Silva et al., 2024).
- Liver Injury Alleviation: Highlighting its therapeutic applications, NAC is used in alleviating acetaminophen overdose-induced liver injury, underlining its potential use in clinical settings and importance in developing therapeutic IVD assays (Chen et al., 2024).
- Enhanced Cancer Treatment Efficacy: Employed in combination therapies, NAC is used to treat posterior gastric pseudomyxoma peritonei, offering insights into its role as a biochemical agent that enhances the efficacy of cancer treatments in diagnostic and therapeutic applications (Sun et al., 2024).
- Regulation of Cell Cycle and Autophagy: NAC′s interactions with 1-Methoxyisobrassinin in ovarian cancer cells illustrate its capability to modulate cell cycle regulation, apoptosis, and autophagy, underpinning its significant role in the development of biomarker detection assays and other IVD products (Zigová et al., 2024).
Biochem/physiol Actions
Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Klasa składowania
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
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Journal of medicinal chemistry, 58(11), 4494-4505 (2015-05-12)
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Michael Berk et al.
Trends in pharmacological sciences, 34(3), 167-177 (2013-02-02)
N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. This review summarises the areas where the mechanisms of action of
Yuval Samuni et al.
Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity
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The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (Nlrp3) inflammasome plays an important role in inflammation by controlling the maturation and secretion of the cytokines IL-1β and IL-18 in response to multiple stimuli including pore-forming toxins, particulate matter, and ATP.
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